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Hot-melt extrusion
Process optimization of twin-screw melt granulation of fenofibrate using design of experiment (DoE)
The purpose of this study was to optimize the melt granulation process of fenofibrate using twin-screw granulator. Initial screening was performed to select the excipients required for melt granulation process. A 3 × 3 factorial design was used to optimize the processing conditions using the % drug…
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Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion
Implantable drug delivery systems (IDDSs) offer good patient compliance and allow the controlled delivery of drugs over prolonged times. However, their application is limited due to the scarce material selection and the limited technological possibilities to achieve extended drug release. Porous…
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Ternary Amorphous Solid Dispersions Containing a High-Viscosity Polymer and Mesoporous Silica…
The aim of this study was to evaluate the benefits of a ternary amorphous solid dispersion (ASD) that was designed as an immediate-release tablet with a high drug load (e.g., 40% w/w) to produce heightened maintenance of drug supersaturation during dissolution testing, which will be henceforth…
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Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective…
An industrially feasible approach to overcome the solubility and bioavailability limitations of poorly soluble active pharmaceutical ingredients is the development of amorphous solid dispersions (ASDs) using hot-melt extrusion (HME) technique. The application of Quality by Design (QbD) had a…
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Pharmaceutical Co-crystals, Salts, and Co-amorphous Systems: A novel opportunity of hot-melt…
Enhancing the solubility of active drug ingredients is a major challenge faced by scientists and researchers. Different approaches have been explored for the enhancement of solubility and physicochemical properties of drugs, without affecting their stability or pharmacological activity.
Highlights…
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Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines
Over the last few years, conventional medicine has been increasingly moving towards precision medicine. Today, the production of oral pharmaceutical forms tailored to patients is not achievable by traditional industrial means. A promising solution to customize oral drug delivery has been found in…
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Development of Sustained Release Lipid-Based Matrix Microparticles for Vaginal Delivery using…
The development of sustained-release formulations for drugs administered via the vaginal route has the potential to increase treatment efficiency and patient compliance. One promising strategy to formulate such dosage forms is the incorporation of microparticles into a bio-adhesive gel. The main aim…
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Vacuum Compression Molding as a Screening Tool to Investigate Carrier Suitability for Hot-Melt…
Hot-melt extrusion (HME) is the most preferred and effective method for manufacturing amorphous solid dispersions at production scale, but it consumes large amounts of samples when used for formulation development. Herein, we show a novel approach to screen the polymers by overcoming the…
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3D printing of solid oral dosage forms: numerous challenges with unique opportunities
Since the FDA approval of Spritam, there has been a growing interest in the application of 3D printing in pharmaceutical science. 3D printing is a method of manufacturing involving the layer-by-layer deposition of materials to create a final product according to a digital model. There are various…
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Creation of Filaments for 3D Printing via Hot Melt Extrusion: Evaluating Different Downstream…
Purpose: For several years now 3D printing technology has been gaining increasing attention within the pharmaceutical industry. The number of publications is rapidly increasing. One promising 3D printing technology is the fused deposition modeling where a polymer strand is heated and extruded…
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