Browsing Category
Hot-melt extrusion
Effect of Hydroxypropyl Cellulose Level on Twin-Screw Melt Granulation of Acetaminophen
This study investigated the effect of binder level on the physicochemical changes and tabletability of acetaminophen (APAP)-hydroxypropyl cellulose (HPC) granulated using twin-screw melt granulation. Even at 5% HPC level, the tablet tensile strength achieved up to 3.5 MPa. A minimum of 10% HPC was…
Read More...
Read More...
Polymer Selection for Hot-Melt Extrusion Coupled to Fused Deposition Modelling in Pharmaceutics
Three-dimensional (3D) printing offers the greatest potential to revolutionize the future of pharmaceutical manufacturing by overcoming challenges of conventional pharmaceutical operations and focusing design and production of dosage forms on the patient’s needs. Of the many technologies…
Read More...
Read More...
Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products
Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for the first time. For this, a combined mixture design was employed using paracetamol as a model drug. Extrudates were obtained under reduced torque (up to 0.3 Nm) at 100 °C to preserve the stability…
Read More...
Read More...
Preparation of Hot-Melt Extruded Dosage Form for Enhancing Drugs Absorption Based on Computational…
The aim of this study was to control the dissolution rate and permeability of cilostazol. To enhance the dissolution rate of the active pharmaceutical ingredient (API), hot-melt extrusion (HME) technology was applied to prepare a solid dispersion (SD). To control permeability in the gastrointestinal…
Read More...
Read More...
Role of excipients in amorphous solid dispersions
Solid dispersions – a great way to increase the solubility and bioavailability of your drug
In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. Target is an increase in solubility and bioavailability. BASF offers both an comprehensive portfolio…
Read More...
Read More...
Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms
In this work, modified-release solid dosage forms were fabricated by adjusting geometrical properties of solid dosage forms through hot-melt 3D extrusion (3D HME). Using a 3D printer with air pressure driving HME system, solid dosage forms containing ibuprofen (IBF), polyvinyl pyrrolidone (PVP), and…
Read More...
Read More...
Preparation, characterization, and pharmacokinetics of tilmicosin taste-masked formulation via…
Tilmicosin (TMS) is a macrocyclic antibiotic specially used in veterinary clinics, but its extreme bitterness limits its use. This study aimed to obtain a taste-masked formulation of TMS by hot melt extrusion (HME) technology and to investigate the formulation’s characterization, stability, and…
Read More...
Read More...
Hot-Melt Extrusion – Enabling Technologies from Dupont
"Hot melt extrusion (HME), a manufacturing technique traditionally used in the plastic and food industries, is now attracting significant interest from the pharmaceutical manufacturing sector. This is primarily because HME enables the continuous manufacture of a wide variety of dosage…
Read More...
Read More...
Development of a dental pocket drug delivery system based on temperature responsive polymer by the…
Controlled delivery systems are used to improve therapeutic efficacy and safety of drugs by delivering them at a rate dictated by the need of the physiologi- cal environment over a period of treatment to the site of action. A wide variety of polymeric materials, either biodegradable or…
Read More...
Read More...
Compression behaviour of granules produced via twin-screw melt granulation: Effect of initial…
This study focuses on the impact of initial particle size on the tabletability and the deformation behaviour (i.e. plasticity) of granules produced by twin-screw melt granulation (TSMG). As model substances, three different grades of anhydrous dicalcium phosphate (aDCP) were melt-granulated with…
Read More...
Read More...