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Hot-melt extrusion
Resins That Allow Distinctive Drug Delivery Solutions – POLYOX™ product information
POLYOX™ resins are nonionic poly (ethylene oxide) polymers. They are white to off-white, free-flowing hydrophilic powders supplied in a wide variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. POLYOX™ polymers possess thermoplastic…
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Application of 3D printing technology and quality by design approach for development of…
Pediatric population is a sensitive sector of the healthcare and pharmaceutical field with additional needs compared to the adult population. Extemporaneous formulations for children are generally prepared by manipulating adult formulations, but medication errors can result in suboptimal efficacy…
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3D printing of tablets containing amorphous aripiprazole by filaments co-extrusion
30. July 2018
Three-dimensional printing is one of the fastest developing technology within the pharmaceutical field. With many advantages this method can be found as a new dosage form manufacturing technique, however low printing efficiency stays as one of the major limitations.…
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Improvements of theobromine properties using solid dispersions prepared with new technologies
06. November 2017
Abstract
The aim of this study was to improve the pharmaceutical properties of theobromine (TB), particularly its flowability and dissolution rate, by preparing solid dispersions using different technologies (hot melt extrusion—HME, freeze-drying—FD, and…
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Hot melt extrudates formulated using design space: improved palatability and dissolution
31. August 2017
This work aimed to obtain an optimized itraconazole (ITZ) solid oral formulation in terms of palatability and dissolution rate by combining different polymers using hot melt extrusion (HME), according toa simplex centroid mixture design. For this, the polymers…
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Melt Extrusion for a High Melting Point Compound with Improved Solubility and Sustained Release
28. July 2017
Abstract
The objective of the current study was to develop an amorphous solid dispersion for a high melting point compound, griseofulvin (GRF), with an enhanced solubility and a controlled release pattern utilizing hot melt extrusion (HME) technology. Hypromellose…
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The functionality and stability of HPMCAS when used in hot-melt extrusion
31. March 2017
The majority of today’s new chemical entities are poorly water-soluble. One widely used means of overcoming that problem is to develop solid dispersions by mixing at the molecular level the drug candidate into a polymer matrix . Spray drying and hot-melt extrusion…
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Dual-mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion…
Abstract
In the present study, we aimed to prepare a gastroretentive drug delivery system that would be both highly resistant to gastric emptying via multiple mechanisms and would also potentially induce in situ supersaturation. The bioadhesive floating pellets, loaded with an amorphous…
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Engineering hot-melt extruded solid dispersion for controlled release of hydrophilic drugs
Abstract
It is often challenging to precisely manipulate the release behavior of hydrophilic drugs that is believed to be crucial for a satisfactory therapeutic outcome. The aim of this work was to regulate the dissolution of hydrophilic drug from hot-melt extruded solid dispersion via…
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Thermal Processing of PVP- and HPMC-Based Amorphous Solid Dispersions
Abstract
Thermal processing technologies continue to gain interest in pharmaceutical manufacturing. However, the types and grades of polymers that can be utilized in common thermal processing technologies, such as hot-melt extrusion (HME), are often limited by thermal or rheological…
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