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Hot-melt extrusion
Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion…
15. December 2016
Abstract
Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility…
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Continuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation,…
The purpose of this work was to increase the solubility and the dissolution rate of itraconazole, which was chosen as the model drug, by obtaining an amorphous solid dispersion by hot melt extrusion. Therefore, an initial preformulation study was conducted using differential scanning…
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PEO Hot Melt Extrudates for Controlled Drug Delivery: Importance of the Molecular Weight
26. September 2016
Abstract
Poly(ethylene oxide) (PEO)-based hot melt extrudates offer an interesting potential as oral controlled drug delivery systems and can provide additional advantages, such as reducing the risk of drug abuse. Different polymer molecular weight PEOs are…
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Injection Molding as a One-Step Process for the Direct Production of Pharmaceutical Dosage Forms…
26. March 2016
The objective of the present study was to develop a one-step process for the production of tablets directly from primary powder by means of injection molding (IM), to create solid-dispersion based tablets. Fenofibrate was used as the model API, a polyvinyl…
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Modifying release characteristics from 3D printed drug-eluting products
20. March 2016
This work describes an approach to modify the release of active compound from a 3D printed model drug product geometry intended for flexible dosing and precision medication. The production of novel polylactic acid and hydroxypropyl methylcellulose based feed materials…
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Comparison of metoprolol tartrate multiple-unit lipid matrix systems produced by different…
The aim of this study was to develop, evaluate and compare extended release mini-matrices based on metoprolol tartrate (MPT) and either glyceryl behenate (GB) or glyceryl palmitostearate (GPS). Mini-matrices were produced by three different techniques: hot melt extrusion, compression of melt…
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Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion
The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl…
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TASTE-MASKING – Pharmaceutical Taste-Masking Technologies
Taste-masking techniques are applied to mask or overcome the bitter or unpleasant taste of active pharmaceutical ingredients/drugs to achieve patient acceptability and compliance. Oral administration of bitter or unpleasant tasting drugs is often the biggest barrier for patient groups, such as…
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Application of Hot Melt Extrusion Technology in Drug Product Development
26. May 2015
Application of Hot Melt Extrusion Technology in Drug Product Development - 8th Annual Charles I. Jarowski Symposium - June 17-18, 2015St. University, Queens, NY
Hot melt extrusion has been used in the plastic industry for almost 75 years. However, it is only in…
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Capsugel Advances the First Intrinsically Enteric Capsule Technology
Capsugel is a global leader in delivering high-quality, innovative dosage forms and solutions to its customers in the health care industry. The company’s Hard Capsule business unit offers customers the broadest portfolio of gelatin, vegetarian and other specialized capsule…
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