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Hot-melt extrusion
A prediction system: regulating effect of small-molecule additives on properties of amorphous solid…
Abstract
Amorphous solid dispersions (ASDs) with solubility advantage are suffering from the recrystallization risk and subsequent reduced dissolution triggered by high hygroscopicity of hydrophilic polymers and the supersaturation of ASD solutions. To address these issues, in this study,…
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Solid implantable devices for sustained drug delivery
Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug administration routes. Oral and injectable drug administration are the most common routes for drug delivery providing peaks of drug concentrations in blood after administration followed by concentration decay…
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PLGA – A versatile copolymer for design and development of nanoparticles for drug delivery
Introduction
Poly (lactic-co-glycolic acid) or PLGA, a highly hydrophobic copolymer comprised of lactic acid and glycolic acid, has been approved in many drug products and medical devices.1 Over the years since the first approved in 1997, PLGA has been widely studied polymer in the industry because…
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Exploiting common ion addition to accelerate zolpidem hemitartrate release from Eudragit EPO…
The current study aimed at optimizing a previously developed non-clinical formulation for use in zolpidem deprescribing. The formulation under investigation consists of extruded zolpidem hemitartrate (30% w/w) and Eudragit EPO (70% w/w) mixtures which display unsatisfactory dissolution behaviour.…
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3D printing of hollow capsular body & sealing pin by fused filament fabrication (FFF) technique…
Additive manufacturing (AM) is an emerging pharmaceutical manufacturing technique feasible for patient-centric personalised medicine with tailored pharmacotherapy. Fused filament fabrication (FFF) is a highly emphasised 3D printing technology because it is highly economical and user friendly.…
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Parteck® MXP: two polymers, unparalleled value – Polyvinyl alcohol for hot melt extrusion
With two specifically engineered grades of polyvinyl alcohol, Merck´s Parteck® MXP polymers are optimal for generating high performing, solubility enhanced formulations via hot melt extrusion.
Enhancing drug solubility
Parteck® MXP polyvinyl alcohol for HME
Poor active pharmaceutical…
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Formulation and processing of solid self-emulsifying delivery systems (HME S-SEDDS): A single-step…
The objective of the current study is the formulation development and manufacturing of solid self-emulsifying delivery systems (HME S-SEDDS) via a single-step continuous hot-melt extrusion (HME) process. For this study, poorly soluble fenofibrate was selected as a model drug. From the results of…
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Hot-melt extruded in situ gelling systems (MeltDrops Technology): Formulation development, in silico…
In situ gelling systems (ISGS) can prolong retention time and bioavailability of ophthalmic solutions. The complexity and cost of ISGS avert their industrial scale-up and clinical implementation. In this study, we demonstrate novel application of hot-melt extrusion (HME) technology for continuous…
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Solid Formulation Development Using Melt-based 3D Printing Technologies – article by Merck
Three-dimensional (3D) printing is a powerful technology that has wide-ranging applications, including many in the pharmaceutical industry. 3D printing offers the potential to produce medications tailored to the needs of patients and dosage forms in various shapes, sizes, and textures with different…
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Predicting Residence Time and Melt Temperature in Pharmaceutical Hot Melt Extrusion
Hot-melt extrusion is increasingly applied in the pharmaceutical area as a continuous processing technology, used to design custom products by co-processing drugs together with functional excipients. In this context, the residence time and processing temperature during extrusion are critical process…
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