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HPMCAS – Hydroxypropyl methylcellulose acetate succinate
Scaling up Aqueous Enteric Coating with Hypromellose Acetate Succinate (HPMCAS) – Scientific…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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Designing highly porous amorphous celecoxib particles by spray freeze drying leads to accelerated…
Poorly water-soluble drugs are still a major challenge to overcome in order to achieve sufficiently high oral bioavailability. Spray freeze drying (SFD) is proposed here as an alternative for the preparation of amorphous, free-flowing porous celecoxib spheres for enhanced drug dissolution. Tertiary…
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3D printing of pharmaceutical oral solid dosage forms by fused deposition: the enhancement of…
3D printing (3DP) by fused deposition modelling (FDM) is one of the most extensively developed methods in additive manufacturing. Optimizing printability by improving feedability, nozzle extrusion, and layer deposition is crucial for manufacturing solid oral dosage forms with desirable properties.…
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Hot-melt extruded hydroxypropyl methylcellulose acetate succinate based amorphous solid dispersions:…
Nucleation inhibition and maintenance of drug supersaturation over a prolonged period are desirable for improving oral absorption of amorphous solid dispersions. The present study investigates the impact of binary and ternary amorphous solid dispersions on the supersaturation kinetics of nifedipine…
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Impact of Swelling of Spray Dried Dispersions in Dissolution Media on Their Dissolution: An…
Impact of SDD-dissolution medium interactions on the swelling and dissolution of spray dried dispersions (SDDs) was investigated using UV imaging by monitoring SDD swelling in situ, along with correlating of the swelling with the micro-dissolution and intrinsic dissolution of SDDs. SDDs of…
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Role of polymers in the physical and chemical stability of amorphous solid dispersion: A case study…
Incorporating the amorphous drug in polymeric components has been demonstrated as a feasible approach to enhance the bioavailability of poorly water-soluble drugs. The objective of this study was to investigate the role of polymers in the stability of amorphous solid dispersion (ASD) by evaluating…
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Design and Characterization of HY-038 Solid Dispersions via Spray Drying Technology
The aim of this study was to prepare HY-038 solid dispersions (SDs) with single carrier at high drug loading and then forming a tablet to enhance solubility, dissolution, and bioavailability via spray drying technology. At the same time, we hope to develop a more convenient in vitromethod to predict…
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Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of…
The solution behavior and membrane transport of multidrug formulations were herein investigated in a biorelevant medium simulating fasted conditions. Amorphous multidrug formulations were prepared by the solvent evaporation method. Combinations of atazanavir (ATV) and ritonavir (RTV) and felodipine…
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Efficient Development of Sorafenib Tablets with Improved Oral Bioavailability Enabled by…
An amorphous solid dispersion (ASD) of sorafenib (SOR) in hydroxypropyl methylcellulose acetate succinate (HPMC-AS), prepared by coprecipitation, was used to develop an immediate release tablet with improved oral bioavailability. An ASD of 40% drug loading with HPMC-AS (M grade), which exhibited…
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Downstream processing of spray-dried ASD with hypromellose acetate succinate – Roller compaction and…
Despite wide commercial application of hypromellose acetate succinate (HPMCAS) in spray-dried amorphous solid dispersion (ASD) drug products, little information is available in the references on downstream processing of spray-dried dispersions with HPMCAS. Poor flow and high dilution factor are a…
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