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HPMCAS – Hydroxypropyl methylcellulose acetate succinate
Melt Extrusion for a High Melting Point Compound with Improved Solubility and Sustained Release
28. July 2017
Abstract
The objective of the current study was to develop an amorphous solid dispersion for a high melting point compound, griseofulvin (GRF), with an enhanced solubility and a controlled release pattern utilizing hot melt extrusion (HME) technology. Hypromellose…
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The functionality and stability of HPMCAS when used in hot-melt extrusion
31. March 2017
The majority of today’s new chemical entities are poorly water-soluble. One widely used means of overcoming that problem is to develop solid dispersions by mixing at the molecular level the drug candidate into a polymer matrix . Spray drying and hot-melt extrusion…
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Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion
The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl…
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