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Hydroxypropyl methylcellulose acetate succinate (HPMCAS)
Synergistic effect of polymers in stabilizing amorphous pretomanid through high drug loaded…
Pretomanid (PTM), an oral antibiotic used in the treatment of adults with pulmonary extensively drug-resistant, nonresponsive multidrug-resistant tuberculosis (MDR-TB). It is a poor glass former, that shows high recrystallization tendency from the amorphous and supersaturated state, resulting in low…
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Advantages of combining polymers and lipids in extrusion processes
This poster was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
Hot melt extrusion (HME) has become increasingly popular in pharmaceutical manufacturing over the last
decade1. This…
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Electromagnetic drop-on-demand (DoD) technology as an innovative platform for amorphous solid…
Production of amorphous solid dispersions (ASDs) is an invaluable technique to promote the solubility and bioavailability of medicinal substances. ASD is manufactured using a variety of classic and modern techniques, most of which rely on either melting or solvent evaporation. This proof-of-concept…
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Shin-Etsu AQOAT® – Enteric coating polymer and solid dispersion carrier
Shin-Etsu supplies the various excipients for pharmaceutical industry. Let us introduce you Shin-Etsu AQOAT® Hypromellose acetate succinate (HPMCAS, NF, JP), an enteric coating material that can be used in aqueous or organic media.
Hypromellose is a non-toxic material which has been used in…
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A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE…
Abstract
Background. Amoxicillin trihydrate possesses poor solubility, compressibility, and flow behavior. Amorphous solid dispersion prepared by spray drying could solve all three problems at the same time. Objective. To prepare amorphous solid dispersion after screening of polymers by solvent…
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The challenge of downstream processing of spray dried amorphous solid dispersions into minitablets…
Poorly water-soluble drugs present a significant challenge in the development of oral solid dosage forms (OSDs). In formulation development the appropriate use of excipients to adjust solubility, and the choice of manufacturing method and pharmaceutical processes to obtain a dosage form to meet the…
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Supersaturable diacyl phospholipid dispersion for improving oral bioavailability of brick dust…
This study aims to investigate the potential use of polymer inclusion in the phospholipid-based solid dispersion approach for augmenting the biopharmaceutical performance of Aprepitant (APT). Initially, different polymers were screened using the microarray plate method to assess their ability to…
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Development of Subdermal Implants Using Direct Powder Extrusion 3D Printing and Hot-Melt Extrusion…
Implants are drug delivery platforms that consist of a drug-polymer matrix with the ability of providing a localized and efficient controlled release of the drug with minimal side effects and achievement of the desired therapeutic outcomes with low drug loadings. Direct powder extrusion (DPE) 3D…
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Correlating mechanical and rheological filament properties to processability and quality of 3D…
Filament formulation for FDM is a challenging and time-consuming process. Several pharmaceutical polymers are not feedable on their own. Due to inadequate filament formulation, 3D printed tablets can also exhibit poor uniformity of tablet attributes. To better understand filament formulation…
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Preparation of core-shell controlled release tablets using direct powder extrusion 3D printing…
Three-dimensional printing (3DP) is a widely used technique to manufacture drug delivery systems due to its precision, efficiency, and tailored prescription capability. Although fused deposition modeling (FDM) is the most commonly used technique in the pharmaceutical sciences, there are several…
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