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Hydroxypropyl methylcellulose acetate succinate (HPMCAS)
Impact of polymer type, ASD loading and polymer-drug ratio on ASD tablet disintegration and drug…
Amorphous solid dispersion (ASD) has become an attractive strategy to enhance solubility and bioavailability of poorly water-soluble drugs. To facilitate oral administration, ASDs are commonly incorporated into tablets. Disintegration and drug release from ASD tablets are thus critical for achieving…
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Smart liquids for oral controlled drug release: An overview of alginate and non-alginate based…
Sustaining and controlling the rate of drug release is essential in pharmaceutical technology. It can reduce the number of units administered by the patient with subsequent improvement in patient compliance. These technologies can allow controlled liberation of the active pharmaceutical ingredients…
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Cellulose and its derivatives for application in 3D printing of pharmaceuticals
Background
Three-dimensional printing (3DP) has emerged as an advanced manufacturing technology capable of producing complex yet precise medicines intended for patient-centric drug therapy. However, printable materials currently available for 3DP are far too limited.
Area covered
The current…
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Multiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in…
28. April 2016
Abstract: The aim of this study was to formulate probiotics-loaded pellets in a tablet form to improve storage stability, acid tolerability, and in vivo intestinal protective effect. Bacteria-loaded pellets primarily prepared with hydroxypropyl methylcellulose…
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Solubility parameters of hypromellose acetate succinate and plasticization in dry coating procedures
05. March 2016
Solubility parameters of HPMCAS have not yet been investigated intensively. On this account total and three dimensional solubility parameters of HPMCAS were determined by using different experimental as well as computational methods. In addition, solubility properties…
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