Pharma Excipients
Calcium Carbonate
Water-assisted synthesis of mesoporous calcium carbonate with a controlled specific surface area and…
A carbonation process to control the specific surface area of mesoporous calcium carbonate and the dissolution profile of ferulic acid on mesoporous carbonate particles are presented. The effects of water content on the physicochemical properties, specific surface area, pore size, crystallinity, and…
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Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet…
Fast disintegrating tablets have commonly been used for fast oral drug delivery to patients with swallowing difficulties. The different characteristics of the pore structure of such formulations influence the liquid transport through the tablet and hence affect the disintegration time and the…
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Fully inkjet‐printed glucose assay fabricated on highly porous pigment coating
A simple paper-based microfluidic device, fabricated on a highly porous coating consisting of functionalised calcium carbonate (FCC) pigment and a microfibrillated cellulose (MFC) and/or polyvinyl alcohol (PVOH) binder, was developed for glucose detection. Both the hydrophobic patterns, consisting…
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Compaction behavior of isomalt after roll compaction
Isomalt is a polyol derived from sucrose. Advantages of this excipient are its sweet taste, which is supposed to allow taste masking, the low glycemic and insulinemic response (Petzoldt, 1982), and the ability to be compacted directly. With regard to infantile patients, also the lack of…
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Functionalized calcium carbonate based peptide formulation: aspects of the development for oral…
Diseases and malfunctions of the gastro intestinal tract belong to the most common illnesses in humans. This includes infections, caused by bacteria and fungi as well as food intolerances against a variety of dietary products. The prevalence of such diseases is increasing due to either bacterial…
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Characterization and evaluation of the performance of different calcium and magnesium salts as…
The performance of a series of inorganic salts as direct compression excipients was systematically evaluated.
The physical-chemical and technological properties of the different salts were investigated in terms of crystalline/amorphous state, morphology, granulometry, apparent/tapped density,…
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Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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Loading of Porous Functionalized Calcium Carbonate Microparticles
Accurate analysis of intraparticle distribution of substances within porous drug carriers is important to optimize loading and subsequent processing. Mercury intrusion porosimetry, a common technique used for characterization of porous materials, assumes cylindrical pore geometry, which may lead to…
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Conformational polymorphic changes in the crystal structure of the chiral antiparasitic drug…
Praziquantel is an antiparasitic drug used for decades. Currently, the praziquantel commercial preparation is a racemic mixture, inwhich only the levo-enantiomer possesses anthelmintic activity. The knowledge of its properties in the solid state and other chemical-physical properties is necessary…
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Mouthfeel of ODT with Functionalized Calcium Carbonate
11. October 2017 Orally disintegrating tablets (ODT) are comfortable and safe drug delivery methods beneficial for all age groups of patients. ODTs are characterized by fast disintegration, high physical stability, taste masking…
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