Pharma Excipients
Calcium Carbonate
Influence of calcium carbonate and sodium carbonate gassing agents on pentoxifylline floating…
11. September 2017
Purpose
This study was to design and evaluate effervescent floating tablets with sustained release behaviour. Pentoxifylline is a water-soluble model drug with a short half-life, consequently developing sustained release preparations would be…
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Characterization of new functionalized calcium carbonate-polycaprolactone composite material for…
24. May 2017 Abstract A new mineral–polymer composite (FCC-PCL) performance was assessed to produce complex geometries to aid in development of controlled release tablet…
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Nanoporous Calcium Carbonate-Based Substrates for the Controlled Delivery of Functional Materials
24. May 2017
The overall aim of this project was to study `functionalised' calcium carbonates (FCCs) for use as a carrier for the controlled release of `actives,' by permeation and diffusion, and is being proposed as an environmentally friendly and non-toxic…
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Characterisation of the Pore Structure of Functionalised Calcium Carbonate Tablets by Terahertz…
12. March 2017 Abstract Novel excipients are entering the market to enhance the bioavailability of drug particles by having a high porosity and thus providing a rapid liquid uptake and disintegration to accelerate subsequent…
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Functionalised calcium carbonate: a next-generation mineral excipient
11. October 2016
Orally disintegrating tablets (ODTs) are a preferred dosage form compared with conventional tablets because of the numerous advantages they offer, such as rapid dissolution and fast onset of action.
To maintain the porous structure needed for fast dispersion, most…
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ICH Q3D practical implementation challenges – a dual perspective -Manufacturer and excipient…
28. April 2016
Presentation by Dr Andrew Teasdale AstraZeneca
IPEC Europe Excipients Forum - Making Pharmaceutics 2016
Link to pharm tech article (March 2015)
IPEC Elemental Impurities Lette & Template (incl. Daily Intake Calculator)
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Development and evaluation of floating microparticles for Levofloxacin as a gastroretentive carrier
03. February 2016 Development and evaluation of floating microparticles for Levofloxacin as a gastroretentive carrier Objective: In the present study an effort was initiated to prepare alginate oating microparticles for oral…
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Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery
27. December 2015 Amorphous calcium carbonate (ACC) is known to interact with proteins, for example in biogenic ACC, to form stable amorphous phases. The control of amorphous:crystalline and inorganic:organic ratios in inhalable…
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Application of the central composite design to optimize the calcium carbonate-HPMC co-processed…
05. November 2015 To develop a novel co-processed tablet excipient based on calcium carbonate and hydroxypropyl methylcellulose (HPMC), the central composite design-response surface methodology (CCD-RSM) was applied to optimize…
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Application of the central composite design to optimizing the calcium carbonate-HPMC co-processed…
27. October 2015 To develop a novel co-processed tablet excipient based on calcium carbonate and hydroxypropyl methylcellulose (HPMC), the central composite design-response surface methodology (CCD-RSM) was applied to optimize the…
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