Pharma Excipients
Inorganic Chemicals
Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis…
Epidermolysis bullosa is a genetically heterogenous skin fragility disorder with multiorgan involvement appearing already in newborn children. Severe progressive fibrosis follows skin blistering, mucosa lesions, and wound healing, favouring development of highly aggressive squamous cell carcinomas.…
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Preparation of Acetaminophen with Fujicalin® and a comparison of Fujicalin® with other commercially…
Blending and Content Uniformity ofMicronized Low-Density Acetaminophen Comparison of Fujicalin® with Other DCPA's
Fujicalin® is an innovative Dibasic Calcium Phosphate Anhydrous (DCPA) that provides significantly improved compressibility and flowability when compared to other DCPA's. The blending…
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Solubility enhancement – The Interview with Fuji Chemical
Fuji Chemical Industries specializes in producing porous spray-dried excipients for the pharmaceutical and nutraceutical markets. They spray-dry their excipients to produce free-flowing granules and unique internal structures that enhance compressibility and functionality. These structures are ideal…
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Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a…
Internal lubrication can be associated with reduced tabletability. Deformation mechanism, lubricant type, lubricant blending time and paddle speed (PS) of the forced feeder are known to be influenceable factors. This study investigated the effect of lubricant blending time and PS of forced feeders…
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Construction of calcium carbonate-liposome dual-film coated mesoporous silica as a delayed drug…
As is well known to all, delivering drug precisely to the tumor site is beneficial to improve the antitumor effect. In this study, we reported mesoporous silica nanoparticles (MSNs) coated with dual-film of calcium carbonate (CaCO3) and lipid bilayer (denoted as MSNs@CaCO3@liposomes) innovatively…
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Impact of Vertical Blender Unit Parameters on Subsequent Process Parameters and Tablet Properties in…
The continuous manufacturing of solid oral-dosage forms represents an emerging technology among the pharmaceutical industry, where several process steps are combined in one production line. As all mixture components, including the lubricant (magnesium stearate), are passing simultaneously through…
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Characterization of the viscoelasticity of pharmaceutical tablets using impulse excitation technique
Pharmaceutical tablets can be produced on different kinds of presses that may have very different compaction kinematics. Strain rate sensitivity (SRS) is thus an important property for the powders used to produce pharmaceutical tablets. Viscoelasticity is one of the aspects of the SRS and can be…
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Level A IVIVC for immediate release tablets confirms in vivo predictive dissolution testing for…
A bioequivalence study comparing two fixed dose combination tablets containing 200 mg ibuprofen and 30 mg pseudoephedrine hydrochloride showed bioequivalence for pseudoephedrine AUC and Cmax, but the reference product showed higher Cmax than the test product in fasted conditions. The main difference…
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Exploration of Neusilin® US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of…
Modern pharmaceutical technology still seeks new excipients and investigates the further use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 (NEU), a commonly used inert filler with unique properties that are usable in various pharmaceutical fields of interest. We…
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Wet powder rheometry: The best conditions for wet granulation using diluent and binder in calcium…
Calcium is an important component for bone maintenance and osteoporosis prevention and can be found in tablet dosage form for dietary supplementation. However, as it contains a high amount of elemental calcium (Ca ++ 500 mg), the production of tablets depends on the flow and compaction properties of…
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