Pharma Excipients
Inorganic Chemicals
Continuous direct compression: Development of an empirical predictive model and challenges regarding…
In this study, an empirical predictive model was developed based on the quantitative relationships between blend properties, critical quality attributes (CQA) and critical process parameters (CPP) related to blending and tableting. The blend uniformity and API concentration in the tablets were used…
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Improving Tableting Performance of Lactose Monohydrate by Fluid-Bed Melt Granulation Co-Processing
Co-processing is commonly used approach to improve functional characteristics of pharmaceutical excipients to become suitable for tablet production by direct compression. This study aimed to improve tableting characteristics of lactose monohydrate (LMH) by co-processing by fluid-bed melt granulation…
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A new parameter for characterization of tablet friability based on a systematical study of five…
In this paper, a new parameter highly relevant to tablet friability is proposed based on a systematical study of the tablet quality attributes and texture performances of five different direct compression excipients, including microcrystalline cellulose, starch, lactose, mannitol, and dicalcium…
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Studies on the pH-dependent solubility of various grades of calcium phosphate-based pharmaceutical…
Calcium phosphate-based pharmaceutical excipients, including calcium hydrogen phosphate anhydrous and dihydrate, calcium hydroxide phosphate have been well established in pharmaceutical technology for a very long time. Nowadays, they are of increasing interest to the pharmaceutical industry because,…
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Discover Omya’s state of the art pharmaceutical laboratory here!
Omya continues to build on its mineral expertise with extensive research & development. New facilities and equipment show their commitment to innovation. Their team of pharma experts is working on new tailor-made functional mineral solutions for specific applications, striving to continuously…
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Control Strategy for Process Development of High-Shear Wet Granulation and Roller Compaction to…
In this study, we developed a control strategy for a drug product prepared by high-shear wet granulation and roller compaction using integrated quality by design (QbD). During the first and second stages, we optimized the process parameters through the design of experiments and identified the…
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Omyanutra® 300 DC – Direct compressible, porous excipient for nutraceuticals
Producing nutraceuticals in solid dosage form is complex and faces many challenges. In production, manufacturers choose either wet or dry granulation, or, which is becoming more popular, direct compression. Direct compression (DC) results in the shortest, most efficient and least complex way to…
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Omyanutra® 300 Flash – The all-in-one solution for ODTs and FDTs
The world of nutraceutical tablet formulation is complex and many critical values have to be considered during development - like dissolution properties, shelf-life stability, or exposure to environmental challenges (oxygen, light, humidity and high or low temperatures).
The high number of…
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Design, Development, and Characterization of Amorphous Rosuvastatin Calcium Tablets
This work proposes a methodology for the design, development, optimisation, and evaluation of amorphous rosuvastatin calcium tablets (BCS class II drug). The main goal was to ensure rapid disintegration and high dissolution rate of the active ingredient, thus enhancing its bioavailability. The…
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Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum…
The present study explored vacuum drum drying (VDD) as an alternative technology for amorphous solid dispersions (ASDs) manufacture compared to hot-melt extrusion (HME) and spray drying (SD) focusing on downstream processability (powder properties, compression behavior and tablet performance).…
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