Inorganic Chemicals

The effect of different binders for direct compression on tablet critical quality attributes was investigated. Dicalcium phosphate, lactose and microcrystalline cellulose were used as fillers and combined with ten binders (10, 20 and 30% w/w). Binder properties were linked to tensile strength via…
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Fuji Chemical Industries specializes in producing porous spray-dried excipients for the pharmaceutical and nutraceutical markets. They spray-dry their excipients to produce free-flowing granules and unique internal structures that enhance compressibility and functionality. These structures are ideal…
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In addition to activity, successful biological drugs must exhibit a series of suitable developability properties, which depend on both protein sequence and buffer composition. In the context of this high-dimensional optimization problem, advanced algorithms from the domain of machine learning are…
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At present, the risk of generic substitutions in warfarin tablets is still being discussed. The aim of this study was to assess whether API interactions with commonly used excipients may affect the safety of generic replacement of warfarin sodium tablets. These interactions were observed during an…
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This work reports the preliminary development of paroxetine-containing formulations amenable to hot-melt extrusion coupled to fused deposition modelling-based 3D printing. Polymeric matrices were used alone, or added with processing enhancers (e.g., plasticizer and filler). The polymeric formulation…
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Minerals supplier Omya International AG (Switzerland) announced it will launch two new nutraceutical tablet excipients at this year’s Vitafoods Europe trade show taking place in October. Both new excipients are designed to overcome processing challenges for dietary supplements and improve ease of…
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There are no methods for specific local application of active substances to the mucosa of the esophagus to treat eosinophilic esophagitis or other esophageal diseases. This publication describes the principal in vivo functionality and acceptance of a novel modular drug delivery concept, called…
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Adjusting the thermal response properties of a polymeric compound can significantly improve the usability in a selective laser-sintering process. As previously shown, combining a precise amount of coarse and narrow size distribution fine calcium carbonate fillers results in a potential optimization…
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Novel calcium phosphate-based starter pellets were used to develop a biphasic-release multiple-unit pellet system (MUPS) with diclofenac sodium as a model drug in the form of hard gelatin capsules. For comparative purposes, corresponding formulations based on the inert cores made of microcrystalline…
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Developing new pharmaceuticals is costly and time-consuming. New methods are always in demand for various stages of product development. Investing in the early phases of development can save a significant amount of resources in the long term. Tablet is still the most commonly used pharmaceutical…
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