Pharma Excipients
Inorganic Chemicals
Effect of intra- and extragranular addition of highly porous tribasic calcium phosphate on…
Immediate release, compositionally proportional formulations of acyclovir comprising porous tribasic calcium phosphate were developed and compared with commercial tablets. Comparison of the dissolution behavior was carried out using a compendial method, as well as with the help of a biorelevant…
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Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines
Over the last few years, conventional medicine has been increasingly moving towards precision medicine. Today, the production of oral pharmaceutical forms tailored to patients is not achievable by traditional industrial means. A promising solution to customize oral drug delivery has been found in…
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Stabilization of amorphous drugs – are crystalline inorganic excipients a way forward?
Physical instability arguably is the major challenge in using neat amorphous active pharmaceutical ingredients in everyday tablets and capsules. The conversion of an amorphous form to the crystalline state either during storage or drug dissolution constitutes physical instability of amorphous drugs,…
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Melt Granulation: a Comparison of Granules produced via High-shear Mixing and Twin-screw Granulation
Melt granules of DI-CAFOS® A12 and 15% (w/w) Kolliphor® P407 were manufactured in a twin-screw granulator (TSG) at five different conditions (screw speed and throughput varied) and compared to granules manufactured in a high-shear granulator (HSG) (rotation speed of chopper/impeller and granulation…
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Use of calcium carbonate as an excipient for release of poorly water soluble drugs: The case of…
Carbamazepine (CBZ) is a poorly water soluble drug owing to the Biopharmaceutic Classification System (BCS) class II. It is characterized by a variable bioavailability and by the presence of different polymorphs. In this paper the effects of CaCO3 on the physicochemical properties of CBZ and its…
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Safe, swallowable and palatable paediatric mini-tablet formulations for a WHO model list of…
More than 10 years after the Paediatric Regulation came into place there is still a strong need for pure paediatric medicines for off-patent drug substances. Numerous compounds for which a paediatric formulation does not exist can be found on the WHO Model List of Essential Medicines for Children…
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Raman Spectroscopy as a PAT-Tool for Film-Coating Processes: In-Line Predictions Using one PLS Model…
Although Raman spectroscopy has been described as a potential process analytical technique for tablet coating, it has rarely been transferred from academic studies to commercial manufacturing applications. The reasons for this are probably not only the high level of process understanding and…
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Preparation of delayed-release multiparticulate formulations of diclofenac sodium and evaluation of…
Diclofenac sodium was used as a model drug for preparation of delayed-release (DR) multiparticulates, which were further processed into solid oral dosage forms such as capsules and tablets. Multiple unit pellets systems (MUPS) were prepared from different types of starter pellets (inert cores)…
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Comparison between twin-screw and high-shear granulation – The effect of filler and active…
Highlights
• Twin-screw granulation was less sensitive for liquid amount used.
• API compaction properties had only minor effect on the tablet tensile strength.
• Tablets made of TSG granules had a higher tensile strength than HSG tablets.
• Twin-screw granulation is a good…
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Functionalised calcium carbonate as a coformer to stabilize amorphous drugs by mechanochemical…
The aim of this study was to investigate the amorphization, physical stability and drug release of a model drug, carvedilol (CAR), when loaded onto functionalised calcium carbonate (FCC) using mechanochemical activation (vibrational ball milling). The solid-state characteristics and physical…
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