Pharma Excipients
Inorganic Chemicals
Compaction behavior of isomalt after roll compaction
Isomalt is a polyol derived from sucrose. Advantages of this excipient are its sweet taste, which is supposed to allow taste masking, the low glycemic and insulinemic response (Petzoldt, 1982), and the ability to be compacted directly. With regard to infantile patients, also the lack of…
Read More...
Read More...
Mechanochemical activation with cyclodextrins followed by compaction as an effective approach to…
Rutin is one of the most important flavonoids with poor bioavailability. This work aimed at addressing the issue of poor biopharmaceutical performance of rutin by applying a combination of complexation with secondary processing into tablets. Mechanical activation was the most suitable method of…
Read More...
Read More...
Influence of the Punch Speed on the Die Wall/Powder Kinematic Friction During Tableting
Influence of the compaction speed on the final tablet properties is an important challenge during the scale-up of a solid dosage form. This strain rate sensitivity is generally attributed to the time dependent deformation behavior of the powder. In this work, we studied the influence of the speed on…
Read More...
Read More...
Scaling Tableting Processes from Compaction Simulator to Rotary Presses—Mind the Sub-Processes
Compaction simulators are frequently used in the formulation and process development of tablets, bringing about the advantages of flexibility, low material consumption, and high instrumentation to generate the most possible process understanding. However, their capability of resembling general…
Read More...
Read More...
Impact of Particle and Equipment Properties on Residence Time Distribution of Pharmaceutical…
Paddle feeders are devices commonly used in rotary tablet presses to facilitate constant and ecient die filling. Adversely, the shear stress applied by the rotating paddles is known to affect the bulk properties of the processed powder dependent on the residence time. This study focuses on the…
Read More...
Read More...
A Mathematical Approach to Consider Solid Compressibility in the Compression of Pharmaceutical…
In-die compression analysis is an effective method for the characterization of powder compressibility. However, physically unreasonable apparent solid fractions above one or apparent in-die porosities below zero are often calculated for higher compression stresses.
One important reason for this…
Read More...
Read More...
Elastic recovery in roll compaction simulation
Roll compaction/dry granulation is a widely used granulation method in the pharmaceutical industry. The simulation of the process is of great interest, especially in the early phase of formulation development of solid dosage forms. The hybrid modeling approach allows to predict the roll compaction…
Read More...
Read More...
Hot-melt extruded lipidic pellets for pediatric applications: An investigation of the effects and…
The current study investigates the development of extemporaneous preparation of hot melt extruded diclofenac sodium (Df-Na) pellets processed with glyceryl dibehenate (Compritol® 888 ATO) and dibasic calcium phosphate anhydrous (Fujicalin®) as carriers for pediatric applications.
The extruded…
Read More...
Read More...
INFLUENCE OF BINDER ATTRIBUTES ON BINDER EFFECTIVENESS IN A CONTINUOUS TWIN SCREW WET GRANULATION…
As a switch to continuous twin screw granulation is quickly gaining momentum, the suitability of binders needs to be evaluated towards this novel granulation process. Binder suitability depends on binder effectiveness, which is affected by binder attributes. These critical attributes need to be…
Read More...
Read More...
Towards a molecular understanding of the impact of crystal size and shape on punch sticking
Punch sticking during tablet manufacturing is a common problem facing the pharmaceutical industry. Using several model compounds, effects of crystal size and shape of active pharmaceutical ingredients (API) on punch sticking propensity were systematically investigated in this work to provide…
Read More...
Read More...