Pharma Excipients
Inorganic Chemicals
Along the Process Chain to Probiotic Tablets: Evaluation of Mechanical Impacts on Microbial…
Today, probiotics are predominantly used in liquid or semi-solid functionalized foods, showing a rapid loss of cell viability.
Due to the increasing spread of antibiotic resistance, probiotics are promising in pharmaceutical development because of their antimicrobial effects. This increases the…
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Functionalized calcium carbonate based peptide formulation: aspects of the development for oral…
Diseases and malfunctions of the gastro intestinal tract belong to the most common illnesses in humans. This includes infections, caused by bacteria and fungi as well as food intolerances against a variety of dietary products. The prevalence of such diseases is increasing due to either bacterial…
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Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison…
Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent.
Currently, polymer-based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or co-precipitation are…
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Adjusting the Release Rate of Mesalazine from Matrix Formulations by Addition of various Excipients
Mesalazine is widely used drug compound to treat inflammations within the gastrointestinal tract (GIT). The APIs is mostly supplied as very fine powder with extremely poor flowability and wet granulation is most often used to meet the challenge. However, mesalazine is prone to degradation by several…
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Novel Ultrasonic In-die Measurements during Powder Compression at Production Relevant Speed
A novel ultrasonic instrumentation was successfully implemented in a compaction simulator. A through-transmission set-up was realised with longitudinal and transverse transducers being alternately positioned inside Euro-D-modified punches. Key features of the data acquisition are described.…
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Swelling of Zein Matrix Tablets Benchmarked against HPMC and Ethylcellulose: Challenging the Matrix…
Zein is an insoluble, yet swellable, biopolymer that has been extensively studied for its applications in drug delivery. Here, we screened the effect of co-excipients on the swelling and drug release of zein tablets.
All throughout the study the behavior of zein was benchmarked against that of…
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Applications of mesoporous material for drug delivery
In recent years mesoporous silica is gaining attention because of their emerging applications in drug delivery.
Since their first appearance in materials science in the 1990s, these inorganic carriers have been successfully used in other areas such as catalysis, purification, and adsorption. The…
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Fundamental evaluation and optimization of porous spherical silica for developing functional fine…
Particle coating, a taste-masking technique for drugs, is limited by its long manufacturing time, which is caused by the decrease in the spray rate required to prevent particle agglomeration.
Mesoporous silica particles, which have a high surface area and pore sizes in the range of 2–50 nm,…
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Improvement of tabletability via twin-screw melt granulation: Focus on binder distribution
In this study, the impact of binder distribution on the tabletability and compactibility of granules produced by twin-screw melt granulation was investigated.
To this end, two grades of dicalcium phosphate anhydrous (fine and coarse) were used as model substances (filler) in combination with two…
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Solidifying ticagrelor loaded self-microemulsifying drug delivery system
The aim of this study was to solidify a ticagrelor loaded self-microemulsifying drug delivery system (TCG-SM) with enhanced dissolution and bioavailability of ticagrelor (TCG) for developing TCG-SM granules and tablets.
TCG was dissolved in the self-microemulsifying drug delivery system (SMEDDS)…
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