Inorganic Chemicals

Implication of Quantitative Selection of Each Excipient in Product Development Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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Accurate analysis of intraparticle distribution of substances within porous drug carriers is important to optimize loading and subsequent processing. Mercury intrusion porosimetry, a common technique used for characterization of porous materials, assumes cylindrical pore geometry, which may lead to…
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Most microbial infectious diseases can be treated successfully with the remarkable array of antimicrobials current available; however, antimicrobial resistance, adverse effects, and the high cost of antimicrobials are crucial health challenges worldwide. One of the common efforts in addressing this…
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Glyceryl behenate based-matrix tablets allowed obtaining a sustained release of theophylline for up to 12 hours. The diluent selected as pore-forming agent (lactose or dibasic calcium phosphate anhydrous) affected the drug release and its stability after 3-months storage at 40°. Lactose-containing…
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The aim of this study was to prepare and evaluate Ibuprofen (IBU) solid dispersion tablets with improved dissolution and less sticking using Porous Calcium Silicate (PCS). Solid dispersion granules were prepared using water-based solid dispersion and water-retained PCS with the wet granulation…
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The mechanism of colloidal silica action to improve flow properties of pharmaceutical powders is known to be based on inter-particle force disruption by silica particles adhered to the particle surface. In the present article, the kinetic aspects of this action are investigated, focusing on…
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A new excipient was prepared using natural resources and bio-wastes such as sodium silicate, brine and date palm cellulose. The prepared excipient is water-insoluble silicate salt precipitated in date palm cellulose (WISS-DPC). The aim of this study was to evaluate the potential use of this new…
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The objective of this study is to investigate the variability in physiochemical and spectral properties of commercially available vegetable grade Magnesium Stearate (MgSt) samples, and to assess the correlation between physiochemical properties and near-infrared (NIR) and Raman spectroscopic…
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Magnesium silicate (MgSiO3) when hydrated is most commonly known as “Talc”. In the pharmaceutical industry, talc is used primarily as a glidant to improve powder flow in tablet compression. Of course, talc is also used by the personal care industry in talcum powder as an adsorbent and by the…
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In the present study, a multi-system for solid dispersion (SD) of celecoxib (CXB) was designed to improve its solubility and anti-inflammatory effects in vitro as well as oral absorption in rats. The SD formulations were prepared by a solvent evaporation with a multi-system as the solubilizer; an…
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