Pharma Excipients
Inorganic Chemicals
Preparation and Evaluation of Solid Dispersion Tablets by a Simple and Manufacturable Wet…
09. April 2016
The aim of this study was to prepare and evaluate solid dispersion tablets containing a poorly water-soluble drug using porous calcium silicate (PCS) by a wet granulation method. Nifedipine (NIF) was used as the model poorly water-soluble drug. Solid…
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Rapid-Onset Sildenafil Sublingual Drug Delivery Systems: In Vitro Evaluation and In Vivo…
21. March 2016
The aim of the present study was to prepare sublingual delivery systems for sildenafil and evaluate its relative bioavailability after sublingual administration in rabbits to attain a rapid onset of action with good efficacy at lower doses. For sublingual application,…
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Novel tablet formulation of amorphous indomethacin using wet granulation with a high-speed mixer…
13. March 2016
Solid dispersion techniques are useful for improving the dissolution of poorly water-soluble drugs. This study aimed to produce and evaluate solid dispersion tablets improving the solubility and oral bioavailability of a poorly water-soluble indomethacin…
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A NEW ENHANCED SORBITOL: CALCIUM DIPHOSPHATE COMPOSITE AS A DIRECT COMPRESSION EXCIPIENT: A…
27. February 2016
Objetive: To evaluate and compared the particle and tableting properties of a new sorbitol (SOR) and anhydrous calcium diphosphate (ACD) composite with common excipients used for the preparation of tablets by direct compression such as polyvinylpirrolidone…
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Development and evaluation of floating microparticles for Levofloxacin as a gastroretentive carrier
03. February 2016 Development and evaluation of floating microparticles for Levofloxacin as a gastroretentive carrier Objective: In the present study an effort was initiated to prepare alginate oating microparticles for oral…
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Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery
27. December 2015 Amorphous calcium carbonate (ACC) is known to interact with proteins, for example in biogenic ACC, to form stable amorphous phases. The control of amorphous:crystalline and inorganic:organic ratios in inhalable…
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Magnesium hydroxide carbonate as excipient in pharmaceutical preparations having improved release of…
29. November 2015
The present invention relates to pharmaceutical formulations of active ingredients which have low solubility in aqueous solutions, having improved release of active ingredient, and to a process for the preparation thereof. In particular, these are pharmaceutical…
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Application of the central composite design to optimize the calcium carbonate-HPMC co-processed…
05. November 2015 To develop a novel co-processed tablet excipient based on calcium carbonate and hydroxypropyl methylcellulose (HPMC), the central composite design-response surface methodology (CCD-RSM) was applied to optimize…
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Application of the central composite design to optimizing the calcium carbonate-HPMC co-processed…
27. October 2015 To develop a novel co-processed tablet excipient based on calcium carbonate and hydroxypropyl methylcellulose (HPMC), the central composite design-response surface methodology (CCD-RSM) was applied to optimize the…
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Diffusion and tortuosity in porous functionalised calcium carbonate – Abstract
04. October 2015 Calcium carbonate can be 'functionalized' by use of etching agents such as phosphoric acid to create inter- and intra-particle porosity with a range of morphologies. Functionalized calcium carbonate has potential…
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