Pharma Excipients
Inorganic Chemicals
Formulation-dependent stability mechanisms affecting dissolution performance of directly compressed…
During drug product development, stability studies are used to ensure that the safety and efficacy of a product are not affected during storage. Any change in the dissolution performance of a product must be investigated, as this may indicate a change in the bioavailability. In this study, three…
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The Preparation of Vitamin E Tablets with Fujicalin
See the fourth issue of Fuji Chemical Industries Technical Newsletter. It presents the preparation of vitamin E tablets with Fujicalin® and a comparison with the other commercially available DCPAs.
Vitamin E is a fat-soluble vitamin like A, D and K. It is oily on physical appearance and…
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Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure
Tablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever. This study investigated the effects of temperature and compaction pressure on tablet…
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Using a Material Library to Understand the Change of Tabletability by High Shear Wet Granulation
Understanding the tabletability change of materials after granulation is critical for the formulation and process design in tablet development. In this paper, a material library consisting of 30 pharmaceutical materials was used to summarize the pattern of change of tabletability during high shear…
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In Situ Co-Amorphization of Olanzapine in the Matrix and on the Coat of Pellets
In situ amorphization is a promising approach, considered in the present work, to enhance the solubility and dissolution rate of olanzapine, while minimizing the exposure of the amorphous material to the stress conditions applied during conventional processing. The production of pellets by…
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Omyanutra 300 – A highly compactable porous mineral ingredient
Omya proudly present their new excipient product portfolio : "Omyanutra 300". See the first product in the Portfolio:
Omyanutra 300
A New Generation of Excipients
Nutraceutical formulations consist of a multitude of active ingredients. To enhance the properties and interactions of active…
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PharSQ® Spheres CM – Unique starter spheres for controlled drug release by Budenheim
Technical information:
PharSQ® Spheres CM by Budenheim is a unique co-processed material made of substances fully compliant with pharmacopoeial requirements:
80% w/w Anhydrous dibasic calcium phosphate (Ph.Eur.,USP/NF, JP)
20% w/w Microcrystalline cellulose (Ph.Eur.,USP/NF, JP)
Available…
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The clinical and translational prospects of microneedle devices, with a focus on insulin therapy for…
Abstract
Microneedles have the clinical advantage of being able to deliver complex drugs across the skin in a convenient and comfortable manner yet haven’t successfully transitioned to medical practice. Diabetes mellitus is a complicated disease, which is commonly treated with multiple daily…
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Pharmaceutical Technical Newsletter F-Melt® by Fuji Chemical Industries
See the second issue of Fuji Chemical Industries Technical Newsletter. This issue focuses on achieving higher tablet hardness with pleasant mouth feel at good oral disintegranting (OD) times by addition of other common excipients.
F-Melt® fast melt tablet made easy!
NEWSLETTER HIGHLIGHT…
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Performance comparison of PLA- and PLGA-coated porous bioceramic scaffolds: Mechanical,…
Bioceramics, particularly calcium phosphates, bioactive glasses, and crystalline silicates, are a principal group of biomaterials employed for the regeneration of damaged tissues and therapeutic delivery. The development of ceramic tissue engineering scaffolds with an appropriate combination of…
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