Pharma Excipients
Inorganic Chemicals
Exploiting synergistic effects of brittle and plastic excipients in directly compressible…
Direct compression (DC) is the simplest and most economical way to produce pharmaceutical tablets. Ideally, it consists of only two steps: dry blending of a drug substance(s) with excipients followed by compressing the powder mixture into tablets. In this study, immediate-release film-coated tablets…
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3D printing of bioactive materials for drug delivery applications
Introduction
Three-dimensional (3D) printing, also known as additive manufacturing (AM), is a modern technique/technology, which makes it possible to construct 3D objects from computer-aided design (CAD) digital models. This technology can be used in the progress of drug delivery systems, where…
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Effect of particle characteristics and foaming parameters on resulting foam quality and stability
In this study, the effects of ten different food-grade particles on bubble quality and stabilization of particle-stabilized food foams in batch and continuous foaming with and without polyglycerol ester (PGE) as an emulsifier were investigated. Particle properties, such as contact angle and…
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Exploiting synergistic effects of brittle and plastic excipients in directly compressible…
Direct compression (DC) is the simplest and most economical way to produce pharmaceutical tablets. Ideally, it consists of only two steps: dry blending of a drug substance(s) with excipients followed by compressing the powder mixture into tablets. In this study, immediate-release film-coated tablets…
Read More...
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Implementation of a New Electronic Liquid Dispensing System for Individualized Compounding of Hard…
An automated compounding device can be a useful tool for the rapid and accurate production of small batches for personalized medicine as well as for clinical batches. A novel electronic liquid dispensing system (ELDS) was investigated to produce hard capsules with individualized dose strengths. An…
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Downstream Processing of Amorphous and Co-Amorphous Olanzapine Powder Blends
The work evaluates the stability of amorphous and co-amorphous olanzapine (OLZ) in tablets manufactured by direct compression. The flowability and the compressibility of amorphous and co-amorphous OLZ with saccharin (SAC) and the properties of the tablets obtained were measured and compared to those…
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Development and Use of a Residence Time Distribution (RTD) Model Control Strategy for a Continuous…
Residence-time-distribution (RTD)-based models are key to understanding the mixing dynamics of continuous manufacturing systems. Such models can allow for material traceability throughout the process and can provide the ability for removal of non-conforming material from the finished product. These…
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Development of a long-acting tablet with ticagrelor high-loaded nanostructured lipid carriers
Ticagrelor (TCG), an antiplatelet agent, has low solubility and permeability; thus, there are many trials to apply the pharmaceutical technology for the enhancement of TCG solubility and permeability. Herein, we have developed the TCG high-loaded nanostructured lipid carrier (HL-NLC) and solidified…
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Biochar as a processing additive in poly (butylene adipate-co-terephthalate) (PBAT)
Poly (butylene adipate-co-terephthalate) (PBAT) is a promising alternative to non-biodegradable plastics in agricultural applications. However, it is usually blended with other materials to find a balance of strength, cost, and iodegradability. There is a need to understand the role of additives and…
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Data-driven approach to mitigate quality impact of hygroscopic pharmaceutical raw materials…
The challenges of working with hygroscopic pharmaceutical raw materials can have a significant impact on the industry’s ability to make high-quality medicines. In order to mitigate the impact to the manufacturing process or product quality it is critical to understand the hygroscopicity of the raw…
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