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Lactose
Development and Characterization of Febuxostat Loaded Floating Beads as Gastro-retentive Drug…
Background:
Febuxostat is a BCS class-II drug, used in the treatment of gout. However, because of its lower solubility, a higher and more frequent dose of the drug is required in the treatment.
Objective:
The objective of this research was to develop and evaluate febuxostat-loaded floating…
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Lactose in tablets: functionality, critical material attributes, applications, modifications and…
Abstract
Lactose is one of the most widespread excipients used in the pharmaceutical industry. Because of its water solubility and acceptable flowability, lactose is generally added into tablet formulation to improve wettability and undesirable flowability. Based on quality by design, a better…
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Inhalable dry powder containing lipid polymer hybrid nanoparticles of Nintedanib esylate: In vitro…
The key objective of this research work was to develop and evaluate dry powder for inhalation containing lipid polymer hybrid nanoparticles (LPHNPs) loaded with Nintedanib esylate (NE) to target deep lung for the treatment of idiopathic pulmonary fibrosis (IPF). NE loaded LPHNPs (NE-LPHNPs) were…
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Attribute transmission and effects of diluents and granulation liquids on granule properties and…
This study aims to examine (i) the effect of diluent types (lactose monohydrate, corn starch, and microcrystalline cellulose) and granulation liquids (20% polyvinylpyrrolidone K30, 65% alcohol, and dispersion containing 40% model drug– Pithecellobium clypearia Benth extracted powder) on granule…
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Exploring the influence of magnesium stearate content and mixing modality on the rheological…
Since carrier-based dry powder inhalers (DPIs) suffer from inadequate drug deposition in the lung, an increasing number of marketed products have added magnesium stearate (MgSt) to improve the aerosolization, dispersion, and stability against moisture of DPI. However, for carrier-based DPI, there is…
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Effect of batch-to-batch variation of spray dried lactose on the performance of feeders
With the emergence of quality by design (QbD), it becomes imperative to gain understanding of the impact of batch-to-batch variability of raw materials on the performance of processes. Feeding is the first unit of operation in a continuous manufacturing line and is critical for the final product…
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Fixed-dose dry powder for inhalation of nintedanib, pirfenidone and mycophenolic acid by thin-film…
Nintedanib and pirfenidone have been approved to treat idiopathic pulmonary fibrosis (IPF) by delaying progression of the disease. Recently, mycophenolic acid has also been used as an additive treatment for IPF. This study aims to produce and evaluate fixed-dose combinations (i.e., two-drug and…
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Comparing failure tests on pharmaceutical tablets: Interpretation using experimental results and a…
The mechanical strength is an important quality attribute of pharmaceutical tablets. It can be determined using different failure tests like the Brazilian test or the three-point bending test. Nevertheless, literature shows that different failure tests often give conflicting values of tensile…
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Comparison of Ceolus™ Grades in Continuous Manufacturing (Wet Granulation) – Continuous…
1. Introduction
Until now, batch manufacturing has been the main mode of pharmaceutical manufacture: raw materials are input and processed in a stage of the process then removed for input and process in the next stage of the sequence. However, in recent years, manufacturers have explored…
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A Comprehensive Scientific Survey of Excipients Used in Currently Marketed, Therapeutic Biological…
Purpose
The steady development of biotechnology-derived therapeutic biologics over the last few decades has generated drugs that are now standard medical treatments for a range of indications. While the development of protein products has surged in recent years, the formulation and delivery of…
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