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Lactose
Application of unsupervised and supervised learning to a material attribute database of tablets…
The purpose of this study is to demonstrate the usefulness of machine learning (ML) for analyzing a material attribute database from tablets produced at different granulation scales. High shear wet granulators (scale 30 g and 1000 g) were used and data were collected according to the design of…
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Influence of compression kinetics during tableting of fluidized bed-granulated microorganisms on…
As tablets are convenient to administer to patients, ensure safe dosing and allow cost-effective production on a large scale, they are the favored dosage form for numerous active pharmaceutical ingredients but also for the administration of viable probiotic microorganisms. Granules with viable yeast…
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Comparison of Ceolus™ Grades in Continuous Manufacturing of Tablets using Direct Compression
1. Introduction
The introduction of continuous manufacturing of tablets has been gaining momentum, because it offers reductions in development and manufacturing costs and time and improved reliability of quality assurance.
In this study, grades of Ceolus™, microcrystalline cellulose (MCC) in…
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Control oriented modeling of twin-screw granulation in the ConsiGma-25 production plant
ConsiGmaTM-25 is a continuous production plant integrating a twin-screw granulation, fluid bed drying, granule conditioning, and a tableting unit. The particle size distribution (PSD), active pharmaceutical ingredient (API) content, and liquid content of wet granules after twin-screw granulation…
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Preparation of sustained-release tablets using a solventless-mixing tablet coating technique:…
The aim of this study was to produce sustained-release tablets by V-shaped blending of polymer and tablets without using solvents or heating, and we investigated the design of polymer particles with high coating performance by modifying the structure of the particles using sodium lauryl sulfate.…
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MEGGLE’s sieved, milled and micronized alpha-lactose monyhydrate for dry powder inhalation: InhaLac®
MEGGLE is a pioneer in co-processing technologies that allow simple, robust formulation development and manufacture. Through co-processing, MEGGLE developed highly functional excipients possessing unique qualities for directly compressible immediate and sustained release pharmaceutical solid dosage…
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A review on co-processed excipients used in direct compression of tablet dosage form
Co-processed excipients may enhance functionality and reduce drawbacks of traditional excipients for the manufacture of tablets on a commercial scale. The following study aimed to characterize a range of co-processed excipients that may prove suitable for dispersible tablet formulations prepared by…
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Influence of talc and hydrogenated castor oil on the dissolution behavior of metformin-loaded…
Multi-unit pellet system (MUPS) is of great interest as it is amenable to customization. MUPS comprises multi-particulates, usually as pellets or spheroids, which can be coated with diffusion barrier coatings. One commonly used diffusion barrier coating is the methacrylic acid copolymer, which can…
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MEGGLE presents the new DPI product InhaLac® 180 at RDD Europe 2023
Wasserburg, Germany, May, 2023:
Pharmaceutical lactose specialist MEGGLE Excipients will launch its latest inhalable milled lactose grade, InhaLac® 180 at May’s Respiratory Drug Delivery (RDD) in the South of France.
InhaLac® 180 is tailored to dry powder inhalation (DPI) applications with a…
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Tableting of fluidized bed granules containing living microorganisms
Tablets are the favored dosage form for numerous active pharmaceutical ingredients, among others because they are easy to take, ensure safe dosing and allow cost-effective production on a large scale. This dosage form is also frequently chosen for the administration of viable probiotic …
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