Lactose

Instrumented die is used to measure maximum die-wall pressure (MDP) and residual die-wall pressure (RDP) during powder compaction. This document from MEDELPHARM aims to provide a methodology to characterize powders with this device. Introduction During tablet development, people study ejection…
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General information Direct compression (DC) tablet manufacture is a popular choice because it provides the least complex, most cost effective process to produce tablets compared to other tablet manufacturing approaches. Manufacturers can blend APIs with excipients and compress, making dosage forms…
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Introduction: Dry powder inhalations are an attractive pharmaceutical dosage form. They are environmentally friendly, portable, and physicochemical stable compared to other inhalation forms like pressurized metered-dose inhalers and nebulizers. Sufficient drug deposition of DPIs into the deep lung…
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MEGGLE’s sieved, milled and micronized alpha-lactose monyhydrate for dry powder inhalation: InhaLac® General information The delivery of active pharmaceutical ingredients (APIs) via the lung is becoming increasingly important as ever more patients all over the world suffer from chronic respiratory…
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Binder jetting has the potential to revolutionize the way we produce medicine. However, tablets produced by binder jetting technology can be quite fragile and hard to handle. In this study, the printing process and ink composition were examined to optimize the mechanical properties of tablets. A…
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Dry granulation via roller compaction is increasingly being used as granulation method for the production of oral solid dosage forms. Advantages of roller compaction include a simplified process compared to wet granulation and the inherently continuous nature of the process. A common problem of dry…
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The present contribution deals with a discrete Element Method (DEM) based on a hybrid particulate lattice model to predict the mechanical strength of pharmaceutical tablets. We consider the classical approach based on the Stress Concentration Force (SCF) obtained at a defect of controlled size. The…
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Internal lubrication with magnesium stearate (MgSt) is associated with a reduced tensile strength and prolonged disintegration and dissolution times. In the current study, alternative lubricants to MgSt were compared with regard to lubrication efficacy and their impact on tablet properties. The…
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In this study, a concentration predicting soft sensor was achieved based on the Residence Time Distribution (RTD) of an integrated, three-step pharmaceutical formulation line. The RTD was investigated with color-based tracer experiments using image analysis. Twin-screw wet granulation (TSWG) was…
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The current research attempts different approaches to overcome the poor dissolution of budesonide (a poorly water-soluble drug) from pellet formulations. Various methods such as liqui-pellet (LP) and pellets made of solid dispersion (SDP) were employed and compared to conventional pellets (CP). In…
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