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Lactose
The effect of excipient particle size on the reduction of compactibility after roller compaction
Developing a robust roller compaction process can be challenging, due to the diversity in process parameters and material properties of the components in a formulation. A major challenge in dry granulation is the reduction of tablet strength as a result of re-compaction of the materials. The aim of…
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An Enhanced Stacking Ensemble Method for Granule Moisture Prediction in Fluidized Bed Granulation
Moisture is a crucial quality property for granules in fluidized bed granulation (FBG) and accurate prediction of the granule moisture is significant for decision making. This study proposed a novel stacking ensemble method to predict the granule moisture based on granulation process parameters. The…
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A Novel Faster-Acting, Dry Powder-Based, Naloxone Intranasal Formulation for Opioid Overdose
Objective
To examine the pharmacokinetics and safety of FMXIN001, a new intranasal powder-based naloxone formulation, in comparison to Narcan® nasal liquid spray.
Methods
FMXIN001, was developed by blending drug microspheres with larger lactose monohydrate particles, that serve as diluent and…
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Modelling the Compaction Step of a Platform Direct Compression Process
The ability to predict formulation behaviour at production scale during formulation design can reduce the time to market and decrease product development costs. However, it is challenging to extrapolate compaction settings for direct compression formulations between tablet press models during…
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Process Model Approach to Predict Tablet Weight Variability for Direct Compression Formulations at…
Optimizing processing conditions to achieve a critical quality attribute (CQA) is an integral part of pharmaceutical quality by design (QbD). It identifies combinations of material and processing parameters ensuring that processing conditions achieve a targeted CQA. Optimum processing conditions are…
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Preparation and Characterization of Inhalable Ivermectin Powders as a Potential COVID-19 Therapy
Ivermectin has received worldwide attention as a potential COVID-19 treatment after showing antiviral activity against SARS-CoV-2 in vitro. However, the pharmacokinetic limitations associated with oral administration have been postulated as limiting factors to its bioavailability and efficacy. These…
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A “Sequential Design of Simulations” approach for exploiting and calibrating discrete element…
The flow behaviours of cohesive particles in the ring shear test were simulated and examined using discrete element method guided by a design of experiments methodology. A full factorial design was used as a screening design to reveal the effects of material properties of partcles. An augmented…
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Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis…
Epidermolysis bullosa is a genetically heterogenous skin fragility disorder with multiorgan involvement appearing already in newborn children. Severe progressive fibrosis follows skin blistering, mucosa lesions, and wound healing, favouring development of highly aggressive squamous cell carcinomas.…
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Effect of excipient properties and blend ratio on the compression properties of dry granulated…
In this study, the effect of a systematically varied excipient ratio of a plastic and a brittle material, i.e., microcrystalline cellulose (MCC) and crystalline α-lactose monohydrate (LAC), on the compression properties of dry granulated particles was investigated. Five powders with different…
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Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a…
Internal lubrication can be associated with reduced tabletability. Deformation mechanism, lubricant type, lubricant blending time and paddle speed (PS) of the forced feeder are known to be influenceable factors. This study investigated the effect of lubricant blending time and PS of forced feeders…
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