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Lipid nanoparticles
In vitro and in vivo studies of ocular topically administered NLC for the treatment of uveal…
Uveal melanoma is one of the most common and aggressive intraocular malignancies, and, due to its great capability of metastasize, it constitutes the most incident intraocular tumor in adults. However, to date there is no effective treatment since achieving the inner ocular tissues still constitutes…
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Brain targeted lactoferrin coated lipid nanocapsules for the combined effects of apocynin and…
Apocynin (APO) is a plant derived antioxidant exerting specific NADPH oxidase inhibitory action substantiating its neuroprotective effects in various CNS disorders, including epilepsy. Due to rapid elimination and poor bioavailability, treatment with APO is challenging. Correspondingly, novel…
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Development and characterization of lipid nanocapsules loaded with iron oxide nanoparticles for…
Brain drug delivery is severely hindered by the presence of the blood–brain barrier (BBB). Its functionality relies on the interactions of the brain endothelial cells with additional cellular constituents, including pericytes, astrocytes, neurons, or microglia. To boost brain drug delivery,…
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Precision Engineering of Lipid-Based Nanosystems via Impingement Jet Mixing
Presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
Introduction
Flash nanoprecipitation and emulsification by solvent diffusion, also known as the ‘emulsification by the ouzo effect’, are multi-component…
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Pre-Formulation, Formulation and Pilot Scale-Up Studies to Establish the Qualitative and…
The present study aimed to establish the theoretical qualitative and quantitative formula of a nanoparticle-based dietary supplement suitable for menopause therapy by integrating various herbal active ingredients – e.g. diosgenin – into a nano lipid matrix with vegetable oils. NLCs (nanostructured…
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Implementation of an at-line nanoparticle size analyzer in a continuous nano-manufacturing line…
Presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
Introduction
A Process Analytical Technology (PAT) strategy for process and product monitoring is important to ensure adequate
product quality. This is…
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Nanocarriers for Controlled Release and Target Delivery of Bioactive Compounds
See the new book, edited by Shaba Noore , Shivani Pathania , Pablo Fuciños , Colm P. O'Donnell , Brijesh K. Tiwari.
Description: This brief provides a comprehensive overview of nanocarriers used for nanoencapsulation of bioactive compounds. It includes the basis of encapsulation mechanism,…
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Nanostructured Lipid Carriers for Oral Treatment of Leishmaniasis: Design and Preclinical Evaluation
Pentavalent antimonials are the primary treatment for leishmaniasis due to their proven efficacy and cost-effectiveness. However, they present poor oral absorption, parenteral administration, and serious adverse effects due to prolonged use. Nanostructured Lipid Carriers (NLC) offer a promising…
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Enzyme-Linked Lipid Nanocarriers for Coping Pseudomonal Pulmonary Infection
Would Nanocarriers Complement Biofilm Disruption or Pave Its Road?
Introduction: Cystic fibrosis (CF) is associated with pulmonary Pseudomonas aeruginosa infections persistent to antibiotics.
Methods: To eradicate pseudomonal biofilms, solid lipid nanoparticles (SLNs) loaded with…
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Lipid-based nanoparticles as a promising treatment for the skin cancer
Abstract
The prevalence of skin disorders, especially cancer, is increasing worldwide. Several factors are involved in causing skin cancer, but ultraviolet (UV) light, including sunlight and tanning beds, are considered the leading cause. Different methods such as chemotherapy, radiotherapy,…
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