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Lipid nanoparticles
Research progress of ophthalmic preparations of immunosuppressants
Immune ophthalmopathy is a collection of autoimmune eye diseases. Immunosuppressants are drugs that can inhibit the body’s immune response. Considering drug side effects such as hepatorenal toxicity and the unique structure of the eye, incorporating immunosuppressants into ophthalmic nanodrug…
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Multinational Research Consortium To Advance Nanomedicine Manufacturing
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Multinational Research Consortium to Advance Nanomedicine Manufacturing
Gattefossé, InProcess-LSP, Knauer, Microfluidics, Skyepharma, and the University of Graz join the RCPE-led European Consortium for Continuous Pharmaceutical Manufacturing (ECCPM) to jointly develop a modular,…
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Lipid technology for delivery of gene-editing therapies
Gene-editing technology is moving from the research lab to the clinic — one of the most eagerly anticipated biopharma developments in recent history. One of the biggest hurdles to the development of successful gene-editing therapeutics is effective delivery of the large and sensitive components…
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Fabrication of Sustained Release Curcumin-Loaded Solid Lipid Nanoparticles (Cur-SLNs) as a Potential…
The goal of current research was to develop a new form of effective drug, curcumin-loaded solid lipid nanoparticles (Cur-SLNs) and test its efficacy in the treatment of lung cancer. Different batches of SLNs were prepared by the emulsification–ultrasonication method. For the optimization of…
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Iterative Design of Ionizable Lipids for Intramuscular mRNA Delivery
Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicles for RNA and have enabled the development of RNA-based drugs such as the mRNA COVID-19 vaccines. Functional delivery of mRNA by an LNP greatly depends on the inclusion of an ionizable lipid, and small changes to these lipid…
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High amount of lecithin facilitates oral delivery of a poorly soluble pyrazoloquinolinone ligand…
Preclinical development of deuterated pyrazoloquinolinone ligands, promising drug candidates for various neuropsychiatric disorders, was hindered by unusually low solubility in water and oils. DK-I-60-3 (7-methoxy-d3-2-(4-methoxy-d3-phenyl)-2,5-dihydro-3Hpyrazoloquinolin-3-one) is one of such…
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Innovative lipids for Your Nucleic Acid Delivery research
The history and evolution of Nucleic Acid Delivery systems
mRNA and liposomes were both first discovered in the 1960s, and liposomes were used to deliver mRNA into eukaryotic cells in 1978.1,2 Even with the ability to inject mRNA into cells, there were several technical challenges to overcome…
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Biodegradable Cationic and Ionizable Cationic Lipids: A Roadmap for Safer Pharmaceutical Excipients
Cationic and ionizable cationic lipids are broadly applied as auxiliary agents, but their use is associated with adverse effects. If these excipients are rapidly degraded to endogenously occurring metabolites such as amino acids and
fatty acids, their toxic potential can be minimized. So far,…
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Nano-delivery systems for encapsulation of phenolic compounds from pomegranate peel
Pomegranate fruit is getting more attention due to its positive health effects, and pomegranate peel (PP) is its main byproduct. PP has the potential to be converted from environmentally polluting waste to wealth due to its rich phenolic compounds such as ellagitannins, proanthocyanidins, and…
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Modern Nanocarriers as a Factor in Increasing the Bioavailability and Pharmacological Activity of…
Abstract
This review is devoted to modern systems of nanocarriers that ensure the targeted delivery of flavonoids to various organs and systems. Flavonoids have wide range of effects on the human body due to their antioxidant, anti-inflammatory, antitumor, antimicrobial, antiplatelet and other…
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