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Lipids
Regulatory Considerations for Excipients used in Lipid Nanoparticles
Lipid excipients and delivery systems such as lipid nanoparticles (LNPs) are essential for a wide variety of therapeutics including chemotherapy, analgesics, gene therapy, respiratory and ocular applications, anti-fungal applications, and vaccines (see Figure 2).1 In many cases, these excipients…
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Self-emulsifying drug delivery systems: A versatile approach to enhance the oral delivery of BCS…
Biopharmaceutical classification systems (BCS) class III drugs belongs to a group of drugs with high solubility in gastrointestinal (GI) fluids and low membrane permeability result in significantly low bioavailability. Self-emulsifying drug delivery systems (SEDDS) considered a suitable candidate to…
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Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and…
Benznidazole, a poorly soluble in water drug, is the first-line medication for the treatment of Chagas disease, but long treatment periods at high dosages cause several adverse effects with insufficient activity in the chronic phase. According to these facts, there is a serious need for novel…
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Formulation of Intranasal Mucoadhesive Thermotriggered In Situ Gel Containing Mirtazapine as an…
The purpose of the present work was to develop nanoemulsion-based formulations of mirtazapine for intranasal delivery using a spray actuator to target the brain for treating depression. Research on the solubility of medications in different oils, surfactants, co-surfactants, and solvents has been…
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Dual-Drug-Loaded Topical Delivery of Photodynamically Active Lipid-Based Formulation for Combination…
Topical administration of anti-cancer drugs along with photodynamically active molecules is a non-invasive approach, which stands to be a promising modality for treating aggressive cutaneous melanomas with the added advantage of high patient compliance. However, the efficiency of delivering drugs…
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A state-of-the-art review on solid lipid nanoparticles as a nanovaccines delivery system
In the design of vaccine generation, significant attempts have been made to produce novel vaccines and, as well, to increase the effectiveness of available vaccines versus particular diseases. Over the past few years, with nanovaccines, considerable attention has been paid to increasing vaccine…
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Self-emulsifying drug delivery systems (SEDDS): In vivo-proof of concept for oral delivery of…
In spite of recent progress made in the field of peptide and protein delivery, oral administration of insulin and similar drugs remains a challenge. In this study, lipophilicity of insulin glargine (IG) was successfully increased via hydrophobic ion pairing (HIP) with sodium octadecyl sulfate to…
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The future of mRNA delivery: Advancements in engineering lipid nanoparticles for enhanced…
Messenger RNA (mRNA) has played a crucial role in recent vaccine developments and is at the forefront of much current medical research. Traditionally. the delivery of mRNA systemically via lipid nanoparticles (LNPs) innately results in LNP accumulation in the liver limiting the access to other…
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Use of surfactant-based amorphous solid dispersions for BDDCS class II drugs to enhance oral…
This paper aimed to improve in vitro dissolution/solubility as well as inhibit intestinal metabolism and thus enhance oral bioavailability for a BDDCS class II drug by constructing surfactant-based amorphous solid dispersions using resveratrol (RES) as a model drug. After preliminary screening of…
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Breakthroughs and bottlenecks of psoriasis therapy: Emerging trends and advances in lipid based…
Psoriasis is a chronic autoimmune skin disease characterised by abnormal epidermal keratinocytes, hyperproliferation, and inflammatory infiltration. The main challenges that make treating psoriasis difficult are the complex aetiology, frequency of administration, and multiple side effects of…
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