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Lipids
Nanostructured Lipid Carrier Co-Loaded with Docetaxel and Magnetic Nanoparticles: Physicochemical…
Lung cancer is currently the most prevalent cause of cancer mortality due to late diagnosis and lack of curative therapies. Docetaxel (Dtx) is clinically proven as effective, but poor aqueous solubility and non-selective cytotoxicity limit its therapeutic efficacy. In this work, a nanostructured…
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Formulation, Characterization, and Taguchi Design Study of Eplerenone Lipid-Based Solid Dispersions…
Eplerenone is a potassium-sparing diuretic of aldosterone antagonist employed to treat chronic heart failure and high blood pressure. Eplerenone is classified as a BSC class II drug since it has poor oral absorption and is difficult to absorb in the body. The solid dispersions approach is the most…
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Encapsulation of Morin in Lipid Core/PLGA Shell Nanoparticles Significantly Enhances its…
Morin (3,5,7,2′,4′-pentahydroxyflavone; MR) is a bioactive plant polyphenol whose therapeutic efficacy is hindered by its poor biopharmaceutical properties. The purpose of this study was to develop a nanoparticle (NP) formulation to enhance the bioactivity and oral bioavailability of MR. The…
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Surface Solid Dispersion Review
Oral route is mostly preferred route for administering drugs to patient. But due to the poor solubility many drug has limited used in oral administration. Enhancement of water solubility of poor water soluble drug is a main target in a pharmaceutical field. Surface solid dispersion is aneffective…
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In Vitro and In Vivo Characterization of the Transdermal Gel Formulation of Desloratadine for…
Chronic use of antihistamines can induce abnormalities in lipid absorption with potential excessive accumulation of lipids in the mesentery that can lead to the development of obesity and a metabolic syndrome. The focus of the present work was to develop a transdermal gel formulation of…
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Development, characterization and in vitro cytotoxicity of kaempferol-loaded nanostructured lipid…
Glioblastoma multiforme is the most common and most aggressive human brain cancer. GBM treatment is still a challenge because many drugs are not able to cross the blood-brain barrier, in addition to the increasing resistance to currently available chemotherapy. New therapeutic alternatives are…
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A ready-to-use dry powder formulation based on protamine nanocarriers for pulmonary drug delivery
The use of oral antibiotic therapy for the treatment of respiratory diseases such as tuberculosis has promoted the appearance of side effects as well as resistance to these treatments. The low solubility, high metabolism, and degradation of drugs such as rifabutin, have led to the use of combined…
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Solid microemulsion preconcentrates on pH responsive metal-organic framework for tableting
Poorly water-soluble drugs are frequently formulated with lipid-based formulations including microemulsions and their preconcentrates. We detailed the solidification of drug-loaded microemulsion preconcentrates with the acid-sensitive metal-organic framework ZIF-8 by X-ray powder diffraction and…
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Supersaturating lipid-based solid dispersion of atazanavir provides enhanced solubilization and…
Understanding and controlling the drug solubilization in digestive environment is of great importance in the design of lipid based solid dispersion (LBSD) for oral delivery of poorly aqueous soluble drugs. In the current study we determined the extent of drug solubilization and supersaturation of…
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Development of a sorafenib-loaded solid self-nanoemulsifying drug delivery system: Formulation…
Sorafenib, marketed under the brand name Nexavar®, is a multiple tyrosine kinase inhibitor drug that has been actively used in the clinical setting for the treatment of several cancers. However, the low solubility and bioavailability of sorafenib constitute a significant barrier to achieving a good…
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