Browsing Category
Lipids
Formulation and Evaluation of a Novel Multiparticulate Drug Delivery System for Poorely Water…
Ziprasidone hydrochloride Monohydrate ZHM, chemically 5- ethyl]-6-chloro-1, 3-dihydroindol-2-one hydrochloride; is an atypical antipsychotic with very poor water solubility and less oral bioavailability. The presented research work is about of preparation and evaluation of novel multiparticulate…
Read More...
Read More...
Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures
Messenger RNA (mRNA) lipid nanoparticles (LNPs) have emerged at the forefront during the COVID-19 vaccination campaign. Despite their tremendous success, mRNA vaccines currently require storage at deep freeze temperatures which complicates their storage and distribution, and ultimately leads to…
Read More...
Read More...
Assessment of glyceride-structured oleogels as an injectable extended-release delivery system of…
This manuscript systematically assesses three different glycerides (tripalmitin, glyceryl monostearate, and a blend of mono-, di- and triesters of palmitic and stearic acids (Geleol™)) as potential gelator structuring agents of medium-chain triglyceride oil to form an oleogel-based injectable…
Read More...
Read More...
Start of construction of new U.S. facility for pharmaceutical lipids – Evonik Press Release
Press Release, Health Care, Essen, Germany, March 29, 2023
Facility to secure global supply of functional excipients for RNA medicines
Cooperative agreement with U.S. Government to advance U.S. biopharma industry and ensure pandemic preparedness
Start of production scheduled for 2025…
Read More...
Read More...
Recent Progress of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Ocular Drug…
Abstract
Sufficient ocular bioavailability is often considered a challenge by the researchers, due to the complex structure of the eye and its protective physiological mechanisms. In addition, the low viscosity of the eye drops and the resulting short ocular residence time further contribute to the…
Read More...
Read More...
The development of a solid lipid nanoparticle (SLN)-based lacticin 3147 hydrogel for the treatment…
Chronic wounds affect millions of people globally. This number is set to rise with the increasing incidence of antimicrobial-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus (MRSA), which impair the healing of chronic wounds. Lacticin 3147 is a two-peptide chain…
Read More...
Read More...
Enhancement of in-vitro anti-oral cancer activities of silymarin using dispersion of nanostructured…
Silymarin (SME) shows multiple therapeutic actions against several cancers, however, low aqueous solubility and poor bioavailability issues restrict its clinical use. In this study, SME was loaded in nanostructured lipid carriers (NLCs) and further incorporated in mucoadhesive in-situ gel…
Read More...
Read More...
Quality by Design-Based Development of Solid Self-Emulsifying Drug Delivery System (SEDDS) as a…
For many years, researchers have been making efforts to find a manufacturing technique, as well as a drug delivery system, that will allow for oral delivery of biopharmaceuticals to their target site of action without impairing their biological activity. Due to the positive in vivo outcomes of this…
Read More...
Read More...
A two-pronged approach against glioblastoma: Drug repurposing and nanoformulation design for in…
Glioblastoma (GB) is one of the most lethal types of neoplasms. Its biologically aggressive nature and the presence of the blood-brain barrier (BBB) limit the efficacy of standard therapies. Several strategies are currently being developed to both overcome the BBB and deliver drugs site-specifically…
Read More...
Read More...
Phospholipid-Based Topical Nano-Hydrogel of Mangiferin: Enhanced Topical Delivery and Improved…
Mangiferin is a herbal drug that has proven anticancer potential. Owing to its lower aqueous solubility and poor oral bioavailability, the full pharmacological potential of this bioactive drug has not fully been explored. In the present study, phospholipid-based microemulsion systems were developed…
Read More...
Read More...