Lipids

See the brochure by IOI Oleo Pharma about their Quality & Regulatory: EXCIPIENTS & ACTIVE PHARMACEUTICAL INGREDIENTS - MADE IN GERMANY Founded in 1905, IOI Oleo’s manufacturing site in Witten has been engaged since the beginning of the 1950s in the manufacturing of…
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A mucoadhesive microemulsion of lipophilic silymarin (SLMMME) was developed to treat Parkinson’s disease (PD). Optimization of the SLM microemulsion (ME) was performed using Central Composite Design (CCD). The composition of oil, surfactant, co-surfactant, and water was varied, as per the design, to…
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The goal of this study was to see if microemulsions might be used as a transdermal drug delivery system for acemetacin (ACM). Microemulsions containing isopropyl myristate, Tween 80, Transcutol HP, Labrafil M1944 CS, ethanol, and distilled water were used to create pseudo-ternary phase diagrams. In…
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Cells and tissues are the foundation of translational medicine. At present, one of the main technological obstacles is their preservation for long-term usage while maintaining adequate viability and function. Optimized storage techniques must be developed to make them safer to use in the clinic.…
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Electrospraying (ES) technology is considered an efficient micro/nanoparticle fabrication technique with controlled dimensions and diverse morphology. Gelurice® 48/16 (GLR) has been employed to stabilize the aqueous dispersion of Celecoxib (CXB) for enhancing its solubility and oral bioavailability.…
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Tried & Trusted, Quality & Innovation With our nature-based excipients you can develop modern pharmaceutical topical formulations that combine functionality, regulatory compliance and a pleasant skin feel. While the advantages of localized drug delivery for acute conditions are clear, the…
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Many drugs suffer from low oral bioavailability due to poor intestinal absorption (BCS Classes III and IV, peptides and macromolecules). Formulating with intestinal permeation enhancers can overcome this limiting factor.  Medium chain fatty acids are reputed to increase intestinal permeation, among…
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Gene-editing technology is moving from the research lab to the clinic — one of the most eagerly anticipated biopharma developments in recent history. One of the biggest hurdles to the development of successful gene-editing therapeutics is effective delivery of the large and sensitive components…
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The goal of current research was to develop a new form of effective drug, curcumin-loaded solid lipid nanoparticles (Cur-SLNs) and test its efficacy in the treatment of lung cancer. Different batches of SLNs were prepared by the emulsification–ultrasonication method. For the optimization of…
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Delivery to the brain is a challenging task due to its protection by the blood-brain barrier (BBB). Lipids and fatty acids are reported to affect the permeability of the BBB, although this has not been reported following oral administration. Cannabidiol (CBD) has high therapeutic potential in the…
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