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Lipids
Development and characterization of lipid nanocapsules loaded with iron oxide nanoparticles for…
Brain drug delivery is severely hindered by the presence of the blood–brain barrier (BBB). Its functionality relies on the interactions of the brain endothelial cells with additional cellular constituents, including pericytes, astrocytes, neurons, or microglia. To boost brain drug delivery,…
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Advantages of combining polymers and lipids in extrusion processes
This poster was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
Hot melt extrusion (HME) has become increasingly popular in pharmaceutical manufacturing over the last
decade1. This…
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Self Emulsifying Delivery System of Cissus quadrangularis: Evidence of Enhanced Efficacy and…
Treatment therapies used to manage osteoporosis are associated with severe side effects. So worldwide herbs are widely studied to develop alternative safe & effective treatments. Cissus quadrangularis (CQ) has a significant role in bone health and fracture healing. It is documented that its…
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Precision Engineering of Lipid-Based Nanosystems via Impingement Jet Mixing
Presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
Introduction
Flash nanoprecipitation and emulsification by solvent diffusion, also known as the ‘emulsification by the ouzo effect’, are multi-component…
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Formulation Components’ Role in Shaping Continuous Nanocarrier Production through Impingement…
Presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
The predominant approach for manufacturing nanocarriers on an industrial scale is batch production . Here, a specific quantity of raw…
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Verapamil-Loaded Cubosomes for Enhancing Intranasal Drug Delivery: Development, Characterization, Ex…
Abstract
Verapamil hydrochloride (VRP), an antihypertensive calcium channel blocker drug has limited bioavailability and short half-life when taken orally. The present study was aimed at developing cubosomes containing VRP for enhancing its bioavailability and targeting to brain for cluster…
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Implementation of an at-line nanoparticle size analyzer in a continuous nano-manufacturing line…
Presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
Introduction
A Process Analytical Technology (PAT) strategy for process and product monitoring is important to ensure adequate
product quality. This is…
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Nanostructured Lipid Carriers for Oral Treatment of Leishmaniasis: Design and Preclinical Evaluation
Pentavalent antimonials are the primary treatment for leishmaniasis due to their proven efficacy and cost-effectiveness. However, they present poor oral absorption, parenteral administration, and serious adverse effects due to prolonged use. Nanostructured Lipid Carriers (NLC) offer a promising…
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Formulation development of nanostructured lipid carrier-based nanogels encapsulating tacrolimus for…
The goal of this study was to formulate tacrolimus nanogel based on nanostructured lipid carrier (NLC) in order to improve the efficacy, aesthetic, and patient compliance for the treatment of psoriasis. The microemulsion method was used to create phase diagrams and NLCs were prepared using points…
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Is it advantageous to use quality by design (QbD) to develop nanoparticle-based dosage forms for…
Abstract
Parenteral administration is one of the most commonly used drug delivery routes for nanoparticle-based dosage forms, such as lipid-based and polymeric nanoparticles. For the treatment of various diseases, parenteral administration include intravenous, subcutaneous, and intramuscular…
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