Browsing Category
Lipids
Controlling drug release by introducing lipase inhibitor within a lipid formulation
Drug overdose connected to marketed pharmaceutical products, particularly opioids, occurs at an alarming rate. Novel strategies through innovative formulation approaches that reduce the likelihood of overdose while allowing safe therapeutic outcomes are urgently required. The current study provides…
Read More...
Read More...
Pickering Emulsions: A Novel Tool for Cosmetic Formulators
The manufacturing of stable emulsion is a very important challenge for the cosmetic industry, which has motivated intense research activity for replacing conventional molecular stabilizers with colloidal particles. These allow minimizing the hazards and risks associated with the use of conventional…
Read More...
Read More...
Lipid based nanocarriers: Production techniques, concepts, and commercialization aspect
Over the past decade, compared to all other macromolecules lipid-based nanocarriers have proven to be an excellent carrier and delivery system for various pharmaceutical drugs of poor bioavailability. In addition to that, they exhibit exceptional qualities such as minimal toxicity, economical…
Read More...
Read More...
Hyaluronic acid coated teriflunomide (A771726) loaded lipid carriers for the oral management of…
Systemic rheumatoid arthritis treatment has been associated with numerous side effects. We attempted to formulate hyaluronic acid (HA)-coated teriflunomide (TER)-loaded nanostructured lipid carriers (NLCs) that can target inflamed rheumatic joints following oral administration. In vitro evaluation…
Read More...
Read More...
Long acting injectables for therapeutic proteins
Biotherapeutic development presents a myriad of challenges in relation to delivery, in particular for protein therapeutics. Protein delivery is complicated due to hydrophilicity, size, rate of degradation in vivo, low permeation through biological barriers, pH and temperature sensitivity, as well as…
Read More...
Read More...
Self-emulsifying drug delivery systems: a novel approach to deliver drugs
Self-emulsifying drug delivery systems (SEDDS) are a proven method for poorly soluble substances works by increasing the solubility and bioavailability. SEDDS and isotropic mixtures, are composed of oils, surfactants, and occasionally cosolvents. The ability of these formulations and methods to…
Read More...
Read More...
Self-emulsifying Drug Delivery System for Praziquantel with Enhanced Ex Vivo Permeation
Purpose
In this work, praziquantel (PZQ) was incorporated into self-emulsifying drug delivery system (SEDDS) formulations to demonstrate that the increased apparent solubility and dissolution rate enhance intestinal permeation.
Methods
Solubility measurements of PZQ were performed in lipid…
Read More...
Read More...
Non-melanoma skin cancers: physio-pathology and role of lipid delivery systems in new…
Non-melanoma carcinoma has high incidence rates and has two most common subtypes: basal cell carcinoma and squamous cell carcinoma. This type of carcinoma is usually not fatal; however, it can destroy sensory organs such as the nose, ears, and lips. The treatment of these injuries using non-invasive…
Read More...
Read More...
Controlled release starch-lipid implant for the therapy of severe malaria
Parenteral depot systems can provide a constant release of drugs over a few days to months. Poly-(lactic acid) (PLA) and Poly-(lactide-co-glycolide) (PLGA) are the most commonly used polymers in the production of these systems. Finding alternatives to these polymers is of great importance to avoid…
Read More...
Read More...
Lipid Constituents of Diatoms (Halamphora) as Components for Production of Lipid Nanoparticles
Lipid nanocarriers smaller than 200 nm may be used as pharmaceutical/cosmetic raw materials as they are able to penetrate the skin. The nanostructured lipid carriers (NLCs) based on microalgae oil (Schizochytrium) and lipids extracted from diatoms (Halamphora cf. salinicola (strain SZCZM1454A)) were…
Read More...
Read More...