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Lipids
Spray dried powders for nasal delivery: Process and formulation considerations
Powders for nasal delivery have been recognized as advantageous dosage forms over liquids due to increased stability and residence time on nasal mucosa, with improved bioavailability. They can be manufactured by spray-drying, allowing the optimization of the particle properties that are critical to…
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Better fat bubbles could power a new generation of mRNA vaccines
New lipid delivery systems aim to improve potency and reduce side effects
As any dietician will tell you, some fats are good—and that is surely true of the little fatty balls found in two of the world’s most widely used COVID-19 vaccines. Known as lipid nanoparticles (LNPs), these tiny bubbles of…
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An imidazole modified lipid confers enhanced mRNA-LNP stability and strong immunization properties…
The mRNA vaccine technology has promising applications to fight infectious diseases as demonstrated by the licensing of two mRNA-based vaccines, Comirnaty® (Pfizer/BioNtech) and Spikevax® (Moderna), in the context of the Covid-19 crisis. Safe and effective delivery systems are essential to the…
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Influence of Oil Phase Surface Properties on the Physicochemical Characteristics of Meloxicam…
Introduction
Preparation of self-microemulsifying drug delivery systems (SMEDDS) is a promising delivery approach for drugs with poor aqueous solubility to enhance their dissolution properties and hence oral bioavailability. The objective of the present study was to define the influence of the oily…
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Nanostructured lipid carrier based dermal gel of cyclosporine for atopic dermatitis-in vitro and in…
Cyclosporine is a gold treatment standard for the treatment of atopic dermatitis. Patients demand extended therapy without adverse effects as atopic dermatitis is a chronic condition. The objective of the study was to formulate and evaluate nanostructured lipid carriers (NLC) based dermal gel of…
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Delamination and wetting behavior of natural hot-melt coating materials
In order to achieve a defined product behavior, the coating of particulate solids is an often used process in the food, chemical, and pharmaceutical industries. The wetting behavior affects the coating quality associated with hot-melt coating (HMC) considerably more than the quality associated with…
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Formulation, optimization, and in vitro evaluation of anastrozole-loaded nanostructured lipid…
The present study aims to develop and optimize anastrozole (ANZ)-nanostructured lipid carriers (ANZ-NLCs) for improved anticancer efficacy. In a nutshell, ANZ-NLCs were prepared by a 32 factorial design approach through the solvent evaporation method. In this study, key formulation factors impacting…
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Fabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for…
The aim of this study was to develop a new drug nanocrystals self-stabilized Pickering emulsion (NSSPE) for improving oral bioavailability of quercetin (QT). Quercetin nanocrystal (QT–NC) was fabricated by high pressure homogenization method, and QT–NSSPE was then prepared by ultrasound method with…
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Extrusion and 3D printing of novel lipid-polymer blends for oral drug applications
Lipids are interesting biological materials that can offer a number of pharmaceutical benefits when used as carriers for drug delivery. However, 3D printing of lipids alone by fused deposition processing techniques is very difficult as lipids by themselves have very poor mechanical properties that…
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A lipidic mesophase with tunable release properties for the local delivery of macromolecules: the…
Lipid mesophases are able to incorporate and release a plethora of molecules, spanning from hydrophobic drugs to small hydrophilic proteins and therefore they have been widely used as drug delivery systems. However, their 3–5 nm water channels do not allow the release of large hydrophilic molecules…
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