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Lipids
Lipid Excipients for Drug Delivery – Gattefossé’s new product catalogue
Gattefossé's product catalogue has been refreshed. See the updates:
? Inclusion of their excipients launched in 2021: Emulfree® Duo, Gelucire® 59/14 and Labrafac™ MC60.
? Update of US monograph names for Capryol® 90, Capryol® PGMC and Labrafac™ MC60
? Highlighting excipients with Chinese…
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Development of a potential anti-cancer pulmonary nanosystem consisted of chitosan-doped LeciPlex…
A novel self-assembled lecithin-based cationic nanocarrier (LeciPlex) doped with chitosan was prepared to improve Resveratrol solubility and anticancer efficacy. Using on a machine learning method based on regression analysis, LP5 (composed of lecithin, Peceol® and chitosan) was selected as the…
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Development of self-microemulsifying tablets containing dutasteride for enhanced dissolution and…
This study aimed to develop self-microemulsifying tablets containing the hydrophobic drug dutasteride for easy administration and high in vivo absorption. The candidate lipids and surfactants were formulated into a self-microemulsifying drug delivery system (SMEDDS), and their mean droplet size upon…
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Nanocarriers for promoting skin delivery of therapeutic agents
Compared to oral and injectable administration, a dermal and transdermal drug delivery system that can deliver therapeutic molecules to desired target sites with noninvasive, low toxicity, and convenient self-application is a unique method with high potential and excellent prospects. However, the…
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Pharmacokinetics and Pharmacodynamics of Intranasal Solid Lipid Nanoparticles and Nanostructured…
Nose-to-brain drug delivery has been of great interest for the treatment of many central nervous system (CNS) diseases and psychiatric disorders over past decades. Several nasally administered formulations have been developed to circumvent the blood-brain barrier and directly deliver drugs to the…
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Nanocarrier Systems in Taste Masking
Taste is the most crucial organoleptic parameter affecting patient compliance in the case of drugs with poor palatability. Taste masking is a major challenge for the development of orally ingested active pharmaceutical constituents in the pharmaceutical industry. Numerous conventional taste-masking…
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Formulation performance window for manufacturing cellulose-based sustained-release mini-matrices of…
The aim of the proposed work was to develop robust hot-melt extrusion (HME) process for fabricating sustained-release mini-matrices (pellets) of a highly water-soluble drug, tramadol hydrochloride. The current work was designed to identify a formulation window with target functional performances…
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Lactoferrin-loaded nanostructured lipid carriers (NLCs) as a new formulation for optimized ocular…
Nanostructured lipid carriers (NLC) are novel lipidic nanosystems that provide significant improvements in terms of high drug loading capacity and controlled drug release. The purpose of the present work was based on the design, development, and physicochemical characterization of lactoferrin-loaded…
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Intranasal delivery of insulin by self-emulsified nanoemulsion system: In vitro and in vivo studies
The main objective of this research was to develop a self-emulsified nanoemulsion (SEN) dosage form of insulin where insulin is loaded into the lipid phase of the nanoemulsion for enhanced absorption through intranasal delivery. When loaded into the lipid droplets (oil phase), insulin can be…
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A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory…
Liposomes have been considered promising and versatile drug vesicles. Compared with traditional drug delivery systems, liposomes exhibit better properties, including site-targeting, sustained or controlled release, protection of drugs from degradation and clearance, superior therapeutic effects, and…
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