Browsing Category
Lipids
Oral administration of buparvaquone nanostructured lipid carrier enables in vivo activity against…
Leishmaniasis, a neglected tropical disease, is prevalent in 98 countries with the occurrence of 1.3 million new cases annually. The conventional therapy for visceral leishmaniasis requires hospitalization due to the severe adverse effects of the drugs, which are administered parenterally.…
Read More...
Read More...
Orodispersible Films: A Delivery Platform for Solid Lipid Nanoparticles?
To overcome the poor bioavailability observed for many newly developed active pharmaceutical ingredients (APIs), an appropriate formulation strategy is necessary. One approach is the formulation of these substances in solid lipid nanoparticles and their further processing into solid dosage forms. A…
Read More...
Read More...
Formulation of Lipid-Based Tableted Spray-Congealed Microparticles for Sustained Release of…
Spray-congealing (SPC) technology was utilized to prepare lipid-based microparticles (MP) capable of sustaining the release of Vildagliptin (VG) for use as a once-daily treatment for type 2 diabetes mellitus. VG microparticles were prepared using Compritol®and Gelucire®50/13 as lipid carriers in the…
Read More...
Read More...
Tocopherols as antioxidants in lipid-based systems: The combination of chemical and physicochemical…
Lipid oxidation is a major concern in the food, cosmetic, and pharmaceutical sectors. The degradation of unsaturated lipids affects the nutritional, physicochemical, and organoleptic properties of products and can lead to off-flavors and to the formation of potentially harmful oxidation compounds.…
Read More...
Read More...
A 3D-Printed Polymer–Lipid-Hybrid Tablet towards the Development of Bespoke SMEDDS Formulations
3D printing is a rapidly growing area of interest within pharmaceutical science thanks to its versatility in creating different dose form geometries and drug doses to enable the personalisation of medicines. Research in this area has been dominated by polymer-based materials; however, for poorly…
Read More...
Read More...
Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm
Lipid nanoparticle (LNP) is commonly used to deliver mRNA vaccines. Currently, LNP optimization primarily relies on screening ionizable lipids by traditional experiments which consumes intensive cost and time. Current study attempts to apply computational methods to accelerate the LNP development…
Read More...
Read More...
Study and computational modeling of fatty acid effects on drug solubility in lipid-based systems
Lipid-based systems have many advantages in formulation of poorly water-soluble drugs but issues of a limited solvent capacity are often encountered in development. One of the possible solubilization approaches of especially basic drugs could be the addition of fatty acids to oils but currently, a…
Read More...
Read More...
The impact of quantity of lipid based formulations with different compositions on the oral…
In this study, the effect of the quantity of lipid-based formulations (LBFs) on the oral absorption of ritonavir (RTV), a model for poorly water-soluble drugs, was investigated. Two types of LBFs, comprising short- and medium-chain lipids (LBF-SMC) and long-chain lipids (LBF-LC) loaded with…
Read More...
Read More...
Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded…
Local delivery of drug is a promising strategy to manage periodontitis characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong the drug retention time and exhibit controlled drug permeation through the buccal mucosal layer. This study was…
Read More...
Read More...
Are lipid nanoparticles really superior? A holistic proof of concept study
Lipid nanoparticles are a successful carrier system for dermal drug delivery. They possess various beneficial properties, i.e., increased chemical stability for chemically labile compounds, increased dermal penetration of active compounds, or skin carrying properties after dermal application due to…
Read More...
Read More...