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Lipids
Self-dispersing self-assembling systems for controlled oral delivery of gliclazide
Self-microemulsifying systems undergo self-dispersion to form microemulsion with subsequent self-assembly to form liquid crystalline (LC) and/or gel phases. These transitions modulate the release and absorption pattern of loaded drug. Accordingly, the primary objective was to evaluate these phases…
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Big family of nano- and microscale drug delivery systems ranging from inorganic materials to…
Traditional drug administration routs suffer from low selective distribution, poor solubility, fast elimination and damaging adjacent healthy tissues (especially in cancer therapy). Thus, drug delivery systems (DDSs) which could deliver drug to target site have broadly been investigated to upsurge…
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Natural and bioinspired excipients for dry powder inhalation formulations
Pulmonary drug delivery can have several advantages over other administration routes, in particular when using dry powder formulations. Such dry powder inhalation formulations generally include natural and bio-inspired excipients, which, among other purposes, are used to improve dosing…
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Lipid Based Formulations in Hard Gelatin and HPMC Capsules: A Physical Compatibility Study
Purpose
To investigate the compatibility between hard gelatin and HPMC capsules with a range of different isotropic lipid based formulations containing multiple excipients.
Methods
The miscibility was investigated for 350 systems applying five different oils (Labrafac ™ lipophile WL1349, Maisine®…
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Lipids for pharmaceutical applications from Merck
Lipids are the most commonly used delivery method for RNA therapeutics and vaccines, and lipid nanoparticles could prove a game changer for COVID-19 and many other diseases.
Lipids for passive and active targeting
Surface modification on liposomes is a very effective method to control their…
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Dual Loaded Nanostructured Lipid Carrier of Nano-Selenium and Etravirine as a Potential Anti-HIV…
There is a dire need for dual-long-acting therapy that could simultaneously target different stages of the HIV life cycle and providing a dual-prolonged strategy for improved anti-HIV therapy while reducing oxidative stress associated with the prolonged treatment. Thus, in the present work,…
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Subcutaneously Injectable Hyaluronic Acid Hydrogel for Sustained Release of Donepezil with Reduced…
The daily oral administration of acetylcholinesterase (AChE) inhibitors for Alzheimer’s disease features low patient compliance and can lead to low efficacy or high toxicity owing to irregular intake. Herein, we developed a subcutaneously injectable hyaluronic acid hydrogel (MLC/HSA hydrogel)…
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Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in…
Lipid-based formulations, such as self-microemulsifying drug-delivery systems (SMEDDSs), are promising tools for the oral delivery of poorly water-soluble drugs. However, failure to maintain adequate aqueous solubility after coming into contact with gastrointestinal fluids is a major drawback.
In…
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Lipid Nanoparticles – From Liposomes to mRNA Vaccine Delivery, a Landscape of Research…
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of the COVID-19 mRNA vaccines, LNPs play a key role in effectively protecting and transporting mRNA to cells.…
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Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair
The use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area for the development of new products. Some lipids are usually…
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