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Lipids
Quality by design (QbD) optimization of diazepam-loaded nanostructured lipid carriers (NLC) for…
Diazepam is commonly used in the management of epileptic seizures, although it has limitations that can be overcome by using formulations that are easier to administer and capable of directing the drug to the brain. In this field, it has been reported that the use of nanostructured lipid carriers…
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Design of experiment of redispersible spray dried powder of fatty acid-nanostructured lipid carriers…
Fatty acid such as lauric and oleic acid have been used extensively either in cosmeceutical or pharmaceutical products as an emollient or moisturiser. In this study, fatty acids which combine lauric and oleic acids have been formulated into nanostructured lipid carriers (FA-NLCs) system in order to…
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Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery…
NLCs have provoked the incessant impulsion for the development of safe and valuable drug delivery systems owing to their exceptional physicochemical and then biocompatible characteristics. Throughout the earlier period, a lot of studies recounting NLCs based formulations have been noticeably…
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Design, optimization and pharmacokinetic evaluation of Piribedil loaded solid lipid nanoparticles…
Piribedil (PBD) is an anti-Parkinson’s drug that gained interest recently due to its unique pharmacological profile. But its clinical use is severely limited by drug delivery issues like high dosing frequency (up to 5 tablets/day), low oral bioavailability (<10%), severe GI side-effects, etc. In…
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Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for…
P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse structures out of cells, resulting in poor intestinal permeation and limited bioavailability following oral administration. P-gp inhibitors, including small molecule drugs, natural constituents, and…
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Design and optimization of curcumin loaded nano lipid carrier system using Box-Behnken design
Herbal antioxidant like curcumin holds great potential to treat neurodegenerative disease like Alzheimer's disease. However, its therapeutic potency is obstructed due to rapid metabolism, poor solubility, GI susceptibility, enzymatic degradation and lower bioavailability. Thus, the present work…
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Topical nanocarriers for management of Rheumatoid Arthritis: A review
Rheumatoid arthritis (RA) is a systemic autoimmune disease manifested by chronic joint inflammation leading to severe disability and premature mortality. With a global prevalence of about 0.3%–1% RA is 3–5 times more prevalent in women than in men. There is no known cure for RA; the ultimate goal…
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Encapsulating cannabinoids in lipid-based nanoparticles: CBD vs. CBDA
Enhancing cannabinoids’ therapeutic efficacy
Cannabinoids have a long history in medicine given their therapeutic effects (1). However, due to their lipophilic nature, they are poorly absorbed by the digestive system which hinders their potential as therapeutics (2).
Nanoparticles offer a…
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Fused deposition modeling (FDM)-mediated 3D-printed mouth-dissolving wafers loaded with…
Localized delivery of drugs or nanoparticles for oral cancer is always preferred. Additive manufacturing (AM)-driven 3D-printed wafers to deliver nanoparticles offers a new dimension to the cutting-edge delivery perspective. Nanostructured lipid carriers (NLCs) were loaded inside 3D wafers, printed…
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Molecular Dynamics Simulations to Elucidate Translocation and Permeation of Active from Lipid…
One of the most realistic approaches that could deliver actives (pharmaceuticals/cosmetics) deep into skin layer is encapsulation into nanoparticles (NP). Nonetheless, molecular-level understanding into the mechanism of active delivery from NP to skin has scarcely been studied, compared to their…
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