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Lipids
Structured edible lipid-based particle systems for oral drug-delivery
Oral administration is the most popular and patient-compliant route for drug delivery, though it raises great challenges due to the involvement of the gastro-intestine (GI) system and the drug bioavailability. Drug bioavailability is directly related to its ability to dissolve, transport and/or…
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Galenic Lab-on-a-Chip concept for lipid nanocapsules production
The continuous production of drug delivery systems assisted by microfluidics has drawn a growing interest because of the high reproducibility, low batch-to-batch variations, narrow and controlled particle size distributions and scale-up ease induced by this kind of processes. Besides, microfluidics…
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Storage stability of inhalable, controlled-release powder formulations of ciprofloxacin…
Novel inhalable and controlled release powder formulations of ciprofloxacin nanocrystals inside liposomes (CNL) were recently developed. In the present study, the storage stability of CNL powders consisting of lyoprotectant (i.e. sucrose or lactose), lipids, ciprofloxacin (CIP), and magnesium…
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Dexamethasone-Loaded Nanostructured Lipid Carriers for the Treatment of Dry Eye Disease
Dry eye disease (DED) or keratoconjunctivitis sicca is a chronic multifactorial disorder of the ocular surface caused by tear film dysfunction. Symptoms include dryness, irritation, discomfort and visual disturbance, and standard treatment includes the use of lubricants and topical steroids.…
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Lipophilic Salts and Lipid-Based Formulations: Enhancing the Oral Delivery of Octreotide
Purpose
Successful oral peptide delivery faces two major hurdles: low enzymatic stability in the gastro-intestinal lumen and poor intestinal membrane permeability. While lipid-based formulations (LBF) have the potential to overcome these barriers, effective formulation of peptides remains…
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Solid lipid nanoparticles for hydrophilic drugs
Hydrophilic drugs are proficient therapeutic agents however, delivery of these drugs is a difficult task. Hence, developing an efficient drug delivery system may require a multipronged approach. Colloidal drug delivery systems such as emulsions, liposomes, nanoemulsions, polymeric nanoparticles, and…
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Influence of process and formulation parameters on the preparation of solid lipid nanoparticles by…
A promising strategy to formulate poorly water-soluble active pharmaceutical ingredients (APIs) is the application of these substances in solid lipid nanoparticles. These drug carrier systems are commonly prepared by high-pressure homogenization above the melting temperature of the utilized lipid.…
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Fine powder of lipid microparticles – spray drying process development and optimization
Objectives: Performed studies were focused on developing spray drying technique for aqueous dispersion of solid lipid microparticles (SLM) by selecting appropriate process parameters and assessing their impact on the process and properties of the obtained dry SLM powders.
Significance: Spray…
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Scalable Production of Lipid Nanoparticles Containing Amphotericin B
Lipid-based formulations have been developed to improve stability profiles, tolerability, and toxicity profiles of small molecule drugs. However, manufacture of such formulations involving lipophilic compounds can be labor-intensive and difficult to scale because of solubility and solvent…
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Nanostructured lipid carriers enhances the safety profile of tretinoin: in vitro and healthy human…
Aim: To enhance the tretinoin (TRE) safety profile through the encapsulation in nanostructured lipid carriers (NLC).
Materials & methods: NLC-TRE was developed using a 23 experimental factorial design, characterized (HPLC, dynamic light scattering, differential scanning calorimetry, x-ray…
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