Browsing Category
Lipids
Nanostructured lipid carriers enhances the safety profile of tretinoin: in vitro and healthy human…
Aim: To enhance the tretinoin (TRE) safety profile through the encapsulation in nanostructured lipid carriers (NLC).
Materials & methods: NLC-TRE was developed using a 23 experimental factorial design, characterized (HPLC, dynamic light scattering, differential scanning calorimetry, x-ray…
Read More...
Read More...
Impact of hydrophilic binders on stability of lipid-based sustained release matrices of quetiapine…
Dose dumping is the major drawback of sustained release (SR) matrices. The current research aimed to develop the stable lipid-based SR matrices of quetiapine fumarate (QTF) using GeleolTM (glyceryl monostearate; GMS) as the lipid matrix carrier and KlucelTM EF (HPC EF), Kollidon® VA64, and Kollidon®…
Read More...
Read More...
Development of ketorolac tromethamine loaded microemulsion for topical delivery using D-optimal…
Aim of the present study was to evaluate the potential of microemulsions for the transdermal delivery of ketorolac tromethamine. The pseudo ternary phase diagram, 3 D Optimal mixture design was used to develop the microemulsion of desired properties. Seventeen trial runs were executed by using three…
Read More...
Read More...
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity
Lipid nanoparticles (LNP) are effective delivery vehicles for messenger RNA (mRNA) and have shown promise for vaccine applications. Yet there are no published reports detailing how LNP biophysical properties can impact vaccine performance.
In our hands, a retrospective analysis of mRNA LNP…
Read More...
Read More...
Polymeric and Lipid Nanoparticles: Which Applications in Pediatrics?
This review aims to provide the state of the art on polymeric and lipid nanoparticles, used or suggested to approach pediatric diseases’ problems and needs, and to inspire new researches in this field. Several drugs are currently not available in formulations suitable for pediatric patients.…
Read More...
Read More...
TPGS and chondroitin sulfate dual-modified lipid-albumin nanosystem for targeted delivery of…
Multidrug resistance (MDR) remains the primary issue leading to the failure of chemotherapy. In this study, a d-α-tocopherol polyethylene 1000 glycol succinate (TPGS) and chondroitin sulfate (CS) dual-modified lipid-albumin nanosystem was constructed for targeted delivery of paclitaxel (PTX) in…
Read More...
Read More...
Lipids for pharmaceutical applications from Merck – Millipore Sigma
Lipids are the most widely used delivery system for mRNA therapeutics. Lipid nanoparticles (LNPs) provide a safe and effective drug delivery system to target COVID-19 and other diseases. Watch Merck's animated video about lipid nanoparticles and lipids here:
Your global partner for the…
Read More...
Read More...
A Study to Enhance the Oral Bioavailability of S-Adenosyl-L-Methionine (SAME): SLN and SLN…
The endogenous molecule, S-adenosyl-L-methionine (SAMe) is a key factor due to its role in the methylation cycle and modulation of monoaminergic neurotransmission. Since many mental disorders have linked to the monoaminergic system, the level of SAMe in blood and cerebrospinal fluid is important in…
Read More...
Read More...
A promising dual-drug targeted delivery system in cancer therapy: nanocomplexes of…
Various nano-sized protein and lipid complexes are being investigated as drug delivery systems. The encapsulation of more than one drug in a single nanocomplex carrier could enhance the therapeutic potency and afford synergistic therapeutic effects.
In this study, we developed a novel…
Read More...
Read More...
Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical…
The present study is concerned with the QbD-based design and development of luliconazole-loaded nanostructured lipid carriers (NLCs) hydrogel for enhanced skin retention and permeation. The NLCs formulation was optimized employing a 3-factor, 3-level Box-Behnken design. The effect of formulation…
Read More...
Read More...