Browsing Category
Lipids
Intranasal delivery of Naloxone-loaded solid lipid nanoparticles as a promising simple and…
Naloxone is an opioid receptor antagonist that can eradicate all pre-indications of the toxicity and inverse the opioid overdose. However, oral administration of naloxone offers limitations such as its extensive first-pass metabolism that results in poor therapeutic effects. In order to resolve this…
Read More...
Read More...
A New Approach to the Dissolution Tests Management to Obtain Kinetic and Thermodynamic Data: Release…
This study is focused on the use of glyceryl behenate as a lipophilic excipient of matrix tablets providing controlled drug release. The aim of this study was to evaluate activation energy (EA) and changes of the thermodynamic parameters (ΔH, ΔS, ΔG) of a dissolution process. These values, which…
Read More...
Read More...
A Lipid-Based Depot Formulation with a Novel Non-lamellar Liquid Crystal Forming Lipid
Non-lamellar liquid crystal (NLLC)-forming lipids have gained attention as a novel component because of their ability to self-assemble upon contact with body fluids. In this study, a novel NLLC-forming lipid, mono-O-(5, 9, 13-trimethyl-4-tetradecenyl) glycerol ester (C17MGE), and a model drug with a…
Read More...
Read More...
The Influence of Lipid Excipients on Platelet Function and the Pharmacodynamic Effects of Aspirin
The combination of pharmaceutical lipid excipients with aspirin in a novel liquid oral formulation (Vazalore) limits gastrointestinal toxicity of aspirin. This study was performed to determine whether the lipid excipients influence the pharmacodynamic effects of aspirin and determine whether the…
Read More...
Read More...
Critical Review of Lipid-Based Nanoparticles as Carriers of Neuroprotective Drugs and Extracts
The biggest obstacle to the treatment of diseases that affect the central nervous system (CNS) is the passage of drugs across the blood-brain barrier (BBB), a physical barrier that regulates the entry of substances into the brain and ensures the homeostasis of the CNS. This review summarizes current…
Read More...
Read More...
The pulmonary route as a way to drug repositioning in COVID-19 therapy
The outbreak of the disease caused by the new coronavirus (COVID-19) has been affecting society’s routine and its patterns of interaction worldwide, in addition to the impact on the global economy. To date, there is still no clinically effective treatment for this comorbidity, and drug…
Read More...
Read More...
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP…
Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption.…
Read More...
Read More...
Lipid excipients to unlock oral bioavailability issues
Many active pharmaceutical ingredients have poor water-solubility and/or low permeability, leading to bioavailability issues. Lipid-based formulation (LBF) is a well-known strategy to overcome these hurdles and increase in vivo drug exposure. Depending on their composition, LBF exhibit different in…
Read More...
Read More...
Meclizine-loaded nanostructured lipid carriers to manage nausea and vomiting: Oral bioavailability…
Meclizine shows poor oral bioavailability and slow onset of action due to its low water solubility and poor permeability. In the present study, meclizine-loaded nanostructured lipid carriers (NLCs) were developed to improve oral bioavailability of meclizine. NLCs were prepared using Gelucire…
Read More...
Read More...
A One-Step Twin-Screw Melt Granulation with Gelucire 48/16 and Surface Adsorbent to Improve the…
Fenofibrate is an effective lipid-lowering drug; however, its poor solubility and high log p (5.2) result in insufficient absorption from the gastrointestinal tract, leading to poor bioavailability. In this study, a one-step continuous twin-screw melt granulation process was investigated to improve…
Read More...
Read More...