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Lipids
Third-generation solid dispersion combining Soluplus and poloxamer 407 enhances the oral…
Resveratrol is a very promising anti-oxidant drug candidate with low oral bioavailability due to its intrinsic poor water solubility, intestinal efflux and metabolization mechanisms. Resveratrol solubility high-throughput screening with different carriers was performed showing an enhancement above…
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Biopharmaceutical and pharmacokinetic aspects of nanocarrier-mediated oral delivery of poorly…
Many new chemical entities have limited water solubility and therefore show low and/or variable oral bioavailability. Among the various strategies to overcome this challenge, nanoformulations have emerged as an attractive strategy to improve the oral permeability and absorption of many hydrophobic…
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Phytophospholipid Complex of Caffeic Acid: Development, In vitro Characterization, and In Vivo…
Caffeic acid (CA), a hydroxycinnamic acid possessing a variety of pharmacological activities, has caused a growing interest for the treatment of hyperlipidemia and associated conditions. This work endeavored to develop a novel formulation of CA-Phospholipon® 90H complex (CA-PC) using a solvent…
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Successful drug development with synthetic lipids: critical aspects and strategies
Lipids are gaining enhanced momentum due to their vital role in the field of RNA therapeutics and vaccine development for diseases such as cancer and COVID-19.
Currently, there are 18 liposomal drugs approved by the U.S. Food and Drug Administration (FDA) and hundreds of lipid based drug…
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Enhanced oral bioavailability of nintedanib esylate with nanostructured lipid carriers by lymphatic…
The present research work was aimed to explore the ability of nanostructured lipid carriers (NLCs) to improve oral bioavailability of Nintedanib esylate (NE) via lymphatic uptake. The NE loaded NLCs (NE-NLCs) were fabricated using high speed homogenization followed by probe sonication method and…
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Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement…
This study aims to examine the contribution of nanoporous silica entrapped lipid-drug complexes (NSCs) in improving the solubility and bioavailability of dutasteride (DUT). An NSC was loaded with DUT (dissolved in lipids) and dispersed at a nanoscale level using an entrapment technique.
NSC…
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Development and optimization of chitosan coated nanoemulgel of telmisartan for intranasal delivery:…
Dementia is a degenerative brain disease, which is associated with severe cognitive impairments, where angiotensin receptor blockers (e.g., telmisartan) shown to attenuate demented conditions. The objective of this study is to formulate and characterize telmisartan mucoadhesive nanoemulgel (TMNEG)…
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What are the Ingredients and Excipients in the COVID-19 Vaccines? Update including Novavax Vaccine
What's in a vaccine?
With the emergence of COVID-19, the crucial role that vaccines play in protecting our health has come into sharp focus. During this pandemic hope comes in the form of a vaccine and immunologists around the world are working to develop a vaccine that will protect us against…
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Cilostazol Solubilization and Stabilization Using a Polymer-Free Solid Dispersion System
The development of pH-independent drugs is difficult because it involves improvements in their solubility and dissolution (%) in solubilizer. In the present study, the pH-independent cilostazol (CLT) was formulated for enhanced solubility and dissolution (%) and for maintaining stability with…
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Lipid-based formulations: winning strategy for oral bioavailability enhancement
Many drugs exhibit poor solubility and/or permeability leading to weak oral bioavailability. To overcome these issues different technologies have been developed. Among them, lipid-based formulation (LBF) is a worth-considering option as it can be used from the very beginning of drug development to…
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