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Lipids
Nanostructured lipid carriers as a strategy for encapsulation of active plant constituents:…
Active plant constituents obtained from edible sources have manifested their pharmacological potential as a therapy against several diseases. But the lack of their desired physicochemical properties such as solubility, permeability ultimately leads to poor bioavailability. Two potent active plant…
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Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders
The treatment of various central nervous system (CNS) diseases has been challenging, despite the rapid development of several novel treatment approaches. The blood–brain barrier (BBB) is one of the major issues in the treatment of CNS diseases, having major role in the protection of the brain but…
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Optimization and evaluation of propolis liposomes as a promising therapeutic approach for COVID-19
The present work aimed to develop an optimized liposomal formulation for enhancing the anti-viral activity of propolis against COVID-19. Docking studies were performed for certain components of Egyptian Propolis using Avigan, Hydroxychloroquine and Remdesivir as standard antivirals against both…
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Better Medicines for Older Patients: Considerations between Patient Characteristics and Solid Oral…
Oral drug administration provided as solid oral dosage forms (SODF) remains the major route of drug therapy in primary and secondary care. There is clear evidence for a growing number of clinically relevant swallowing issues (e.g., dysphagia) in the older patient population, especially when…
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Advances in lipid carriers for drug delivery to the gastrointestinal tract
Lipid-based formulations have reemerged as oral drug delivery systems. Advances in the techniques to evaluate the in vivo fate of the formulations, together with an improved knowledge of the gastrointestinal-related processes/barriers to the evolving lipid-based systems, could explain, at least…
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What are the Ingredients and Excipients in the COVID-19 Vaccines?
Covid-19 vaccination has been a big topic and we were curious on the role of excipients in such formulations. Not surprisingly both Pfizer-BioNTech and Moderna (source FDA) have quite similar compositions: Active Ingredient, Lipids and a saline solution. Lipid (oil) "bubbles" are tiny bubbles of…
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Exploring precipitation inhibitors to improve in vivo absorption of cinnarizine from supersaturated…
Supersaturated lipid-based drug delivery systems are increasingly being explored as a bio-enabling formulation approach, particularly in preclinical evaluation of poorly-water soluble drugs. While increasing the drug load through thermally-induced supersaturation resulted in enhanced in vivo…
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Exosomes as Drug Delivery Systems: Endogenous Nanovehicles for Treatment of Systemic Lupus…
Exosomes, nanometer-sized lipid-bilayer-enclosed extracellular vesicles (EVs), have attracted increasing attention due to their inherent ability to shuttle proteins, lipids and genes between cells and their natural affinity to target cells. Their intrinsic features such as stability,…
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Lipids for Taste Masking and Taste Assessment in Pharmaceutical Formulations
Pharmaceutical products often have drawbacks of unacceptable taste and palatability which makes it quite difficult for oral administration to some special populations like pediatrics and geriatrics. To curb this issue different approaches like coating, granulation, extrusion, inclusion complexation,…
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Lipid-based formulations: A winning strategy for oral bioavailability enhancement
The key to lipid-based formulation success relies in the right selection of the lipid excipients to develop an optimized formulation, enabling solubilization of the drug throughout the digestion process for enhancement of oral bioavailability.
If you are not familiar with lipid-based formulation,…
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