Lipids

The current investigation illustrates high drug loading of Paclitaxel (PTX) in lipid- and biosurfactant-based core–shell-type nanocapsules for improving therapeutic potential and reducing toxicity of PTX. The nanocapsules were prepared using the antisolvent precipitation technique having a particle…
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December 3rd, 2020 - Written by Natalia Sannikova, R&D Manager, Ascension Sciences Introduction Solubility of hydrophobic drugs such as cannabinoids can be greatly improved by liposome encapsulation. Lipid composition can be adjusted depending on the type of drug molecule or target tissue.…
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The aim of the study was to develop a novel buccal dosage form to transport rhodamine 123 and human insulin as models for poorly water-soluble and biological drugs, using lipid-core micelles (LCMs)-loaded mucoadhesive films. LCMs were synthesized by a low-energy hot emulsification process, yielding…
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Article by Henri Deda  - Communications Officer at Lipotype The full article was first published on https://www.lipotype.com, and you can read the original article here Summary • Pseudomonas aeruginosa is a multi resistant bacterium • Lipidomics proved the role of lipid metabolism in the…
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The aim of this study was to fabricate novel self-supporting tacrolimus suppositories using semisolid extrusion 3-dimensional printing (3DP) and to investigate their efficacy in an experimental model of inflammatory bowel disease. Blends of Gelucire 44/14 and coconut oil were employed as lipid…
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Sildenafil citrate is a drug used throughout the world primarily to treat erectile dysfunction. Several problems with the commercially available product decrease its efficacy, such as limited solubility, delayed onset of action, and low bioavailability with a large variability in the absorption…
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Supersaturated silica-lipid hybrids have previously demonstrated improved in vitro solubilisation and in vivo oral bioavailability of poorly water-soluble drugs, however were only fabricated using a single lipid (LFCS type I formulations) and were not compared to their liquid precursors. This study…
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Since the development of self-emulsifying drug delivery systems (SEDDS) in 1980's, they attract the attention of researchers in order to confront the challenge of poor water-solubility of orally given drugs. Within recent years, SEDDS were also discovered for oral administration of hydrophilic…
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Sustaining and controlling the rate of drug release is essential in pharmaceutical technology. It can reduce the number of units administered by the patient with subsequent improvement in patient compliance. These technologies can allow controlled liberation of the active pharmaceutical ingredients…
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Rapamycin has been used topically to treat facial angiofibromas associated with tuberous sclerosis for more than a decade. In the absence of a commercial form, a large number of formulations have been clinically tested. However, given the great heterogeneity of these studies, particularly with…
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