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Lipids
Development of Sustained Release Lipid-Based Matrix Microparticles for Vaginal Delivery using…
PURPOSE
The development of sustained-release formulations for drugs administered via the vaginal route has the potential to increase treatment efficiency and patient compliance.
One promising strategy to formulate such dosage forms is the incorporation of microparticles into a bio-adhesive…
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Tailoring lipid nanoconstructs for the oral delivery of Paliperidone
The present research work involves Quality by Design (QbD)-based fabrication of lipid nanoconstructs (LNC) of paliperidone (PPD) bearing superior biopharmaceutical attributes.
Highlights
Lipid nanoconstructs (LNC) is a potential carrier for augmenting the solubility and bioavailability of the…
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Liquisolid tablets – A rationale for formulation and process design
A significant proportion of new API’s in development are poorly soluble and require alternative formulation approaches to achieve adequate oral bioavailability. One option is to develop lipid-based formulations. Lipid formulations are typically liquids but can be converted into solid dosage forms…
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Development of Sustained Release Lipid-Based Matrix Microparticles for Vaginal Delivery using…
The development of sustained-release formulations for drugs administered via the vaginal route has the potential to increase treatment efficiency and patient compliance. One promising strategy to formulate such dosage forms is the incorporation of microparticles into a bio-adhesive gel. The main aim…
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Anti-obesity effect with reduced adverse effect of the co-administration of mini-tablets containing…
The purpose of this study was to develop an oral dosage form of orlistat for the treatment of obesity with reduced adverse effects, for example, fatty and oily stool that have been reported to be associated with the mechanism of action of orlistat. Based on the in vitro results obtained in this…
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Cationic self-nanoemulsifying formulations of tamoxifen with improved biopharmaceutical attributes…
A cationic nanoemulsion of tamoxifen (Tmx) containing a charge inducer was developed for improving biopharmaceutical attributes and anticancer potential of the drug. The lipidic formulation constituted of corn oil, labrasol and transcutol HP and optimized using a mixture design by selecting these…
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Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds
Phenolic compounds are one of the most widespread classes of compounds in nature, with several beneficial biological effects being associated with their anti-oxidant and anti-carcinogenic activities. Their application in the prevention or treatment of numerous chronic diseases have been studied, but…
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Micro and Nano-drug Delivery Systems
Traditional drug formulations deliver the payload by releasing it following relatively simple physical laws, such as drug solubility or controlling its diffusion. The drug cannot always be protected from being degraded by the physiologic environment, or from being released before reaching the site…
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Silibinin Loaded Solid Lipid Nanoparticles: Effect of Different Lipids and Surfactants on…
Solid lipid nanoparticles are rapidly developing field of nanotechnology with several potential applications in drug delivery with spherical shape and an average diameter between 1 and 1000 nm. Due to their size and its properties, solid lipid nanoparticles as drug delivery carrier have shown…
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Repositioning miconazole nitrate for malaria: Formulation of sustained release nanostructured lipid…
It has been previously claimed that miconazole (MNZ) has activity against Plasmodium falciparum in vitro. Therefore, this study aims to evaluate the potential of MNZ as an alternative antimalarial agent. MNZ was entrapped in nanostructured lipid carriers (NLC) based on Softisan®154 and soybean oil…
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