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Lipids
Successful Drug Development with Synthetic Lipids: Critical Aspects and Strategies
pharma's almanac - September 29, 2020 PAP-Q3-20-CL-024 - Shiksha Mantri, Ph.D. - Adela Kasselkus, Ph.D.
Lipid-based drug delivery systems offer several advantages, including improving the stability, solubility, bioavailability, and toxicity profiles of active pharmaceutical ingredients (APIs). It…
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A novel method for assessing the coating uniformity of hot-melt coated particles using…
The effectiveness of hot-melt coating depends on its uniformity and the extent to which the surface is completely covered. Compared with solvent-based coating, spreading is more limited in hot-melt coating; thus, the coating uniformity is more affected by the process parameters. This study presents…
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Functionalization of lipid-based formulations for oral delivery of insulin
Insulin is a potent therapeutic molecule used for the treatment of diabetes mellitus type I and late-stage type II. Insulin is usually administered via subcutaneous (s.c.) injection, which bypasses the portal circulation and, in turn, is likely to cause diabetic complications after long-term…
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Role of the Encapsulation in Bioavailability of Phenolic Compounds
Plant-derived phenolic compounds have multiple positive health effects for humans attributed to their antioxidative, anti-inflammatory, and antitumor properties, etc. These effects strongly depend on their bioavailability in the organism. Bioaccessibility, and consequently bioavailability of…
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Improving the dissolution of a water-insoluble orphan drug through a fused deposition modelling…
Lennox-Gastaut Syndrome (LGS) is a rare form of childhood epilepsy. Rufinamide is an orphan drug indicated for the treatment of LGS. Three-Dimensional Printing (3DP) is a process in which solid objects are created based on a digital file by adding materials layer by layer. Fused deposition modelling…
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New pharmaceutical dosage forms used in the treatment of breast cancer. Polymeric micelles
Among all types of cancer encountered in women, breast cancer is the most prevalent, with the highest mortality rate. An increased survival rate is closely related to early diagnosis, the use of high performing screening methods and of selective and adequate treatments. By using the…
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Formulation and Optimization of Fluvastatin Loaded Self-emulsifying Drug Delivery Systems
Abstract-Introduction: The current research is aimed at formulating and evaluating fluvastatin self-nanoemulsifying drug delivery system (SNEDDS).
Materials and Methods: Fluvastatin SNEDDS formulated using sefsol-218 (oil), Cremophor RH40 (surfactant), and propylene glycol…
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Utility of Pickering emulsions in improved oral drug delivery
Pickering emulsions are surfactant-free emulsions stabilized by solid particles. Their unique structure endows them with good stability, excellent biocompatibility, and environmental friendliness. Pickering emulsions have displayed great potential in oral drug delivery.
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Overcoming the dissolution rate, gastrointestinal permeability and oral bioavailability of…
Simvastatin (SIM) and glimepiride (GLM) were co-formulated into nanosuspensions and self-nanoemulsifying drug delivery systems (SNEDDS) to improve their dissolution rate and oral bioavailability. Nanosuspension was prepared by liquid anti-solvent precipitation method, involving supersaturation of a…
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Acyclovir-Loaded Solid Lipid Nanoparticles: Optimization, Characterization and Evaluation of Its…
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infection. Its oral bioavailability is low; therefore, frequent and high doses are prescribed for optimum therapeutic efficacy. Moreover, the current therapeutic regimen of acyclovir is associated with unwarranted adverse…
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