Browsing Category
Lipids
Preparation, optimization and preliminary pharmacokinetic study of curcumin encapsulated turmeric…
The present investigation aimed to develop curcumin loaded turmeric oil microemulsion for brain targeting. An effort has been made to investigate the role of functional components in developing brain targeted formulation which could enhance the bioavailability and uptake of drug in the brain upon…
Read More...
Read More...
Impact of Reverse Micelle Loaded Lipid Nanocapsules on the Delivery of Gallic Acid into Activated…
Gallic acid (GA) is a polyphenolic compound with proven efficacy against hepatic fibrosis in experimental animals. However, it suffers from poor bioavailability and rapid clearance that hinders its clinical investigation. Accordingly, we designed and optimized reverse micelle-loaded lipid…
Read More...
Read More...
Mechanisms of Water Permeation and Diffusive API Release from Stearyl Alcohol and Glyceryl Behenate…
This work aims to develop complimentary analytical tools for lipid formulation selection that offer insights into the mechanisms of in-vitro drug release for solid lipid MR excipients. Such tools are envisioned to aide and expedite the time consuming process of formulation selection and development.…
Read More...
Read More...
Nanostructured lipid carriers loaded with curcuminoids: Physicochemical characterization, in vitro…
Four formulations of nanostructured lipid carriers (NLC) loaded with curcuminoids where prepared, testing two types of solid lipids (Compritol® 888 ATO and Precirol® ATO 5) and two kinds of stabilizers (poloxamer 407 and polysorbate 80). Particle size values between 111 and 214 nm and polydispersity…
Read More...
Read More...
Optimizing Lipid-Based Formulation for Commercial Success – Webinar
Join this live 90-minute virtual workshop to hear experts present on the fundamental principles, strategies, and advantages of lipid-based drug delivery for enabling commercial success. Presentations from BASF and Catalent will demonstrate on how lipid-based drug softgel technology can provide…
Read More...
Read More...
Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment
Ultra-small nanostructured lipid carriers (usNLCs) have been hypothesized to promote site-specific glioblastoma (GB) drug delivery. Envisioning a multitarget purpose towards tumor cells and microenvironment, a surface-bioconjugated usNLC prototype is herein presented. The comeback of co-delivery by…
Read More...
Read More...
Nanoprecipitation: Applications for Entrapping Active Molecules of Interest in Pharmaceutics
Nanoprecipitation technique, also named solvent injection, spontaneous emulsification, solvent displacement, solvent diffusion, interfacial deposition, mixing-induced nanoprecipitation, or flash nanoprecipitation, is recognized as a useful and versatile strategy for trapping active molecules on the…
Read More...
Read More...
Preparation, characterization and improved release profile of ibuprofen-phospholipid association
Ibuprofen is a widely prescribed non-steroidal and anti-inflammatory drug, which is practically insoluble in water and causes gastrointestinal (GI) side effects. Ibuprofen-phosphathidylcholine association (IPA) was prepared by refluxing ibuprofen and phosphathidylcholine in three different molar…
Read More...
Read More...
Tinctures or oily solutions for CBD
Tinctures, as oily solutions, are an ancient mode of preparation of plant extracts, but are still very actual and attractive, especially for cannabinoid formulations. With a straightforward development, they can easily be developed. They are also very convenient for the patients who can take a few…
Read More...
Read More...
Polymeric Precipitation Inhibitor Assisted Supersaturable SMEDDS of Efavirenz Based on Experimental…
Supersaturable SMEDDS, a versatile dosage form, was investigated for improving the biopharmaceutical attributes and eradicating the food effect of poorly water soluble drug efavirenz.
Objective: The present research pursues development of efavirenz loaded supersaturable self-microemulsifying drug…
Read More...
Read More...