Lipids

Semisolid dosage forms are recommended for the dermal care of babies and children. If we look at the ingredients of these preparations, there are still many cases in which there are substances (occlusive agents, preservatives) that no longer meet certain requirements of the modern age, so it is…
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Cannabinoids are challenging APIs to formulate: Being highly lipophilic compounds with low water solubility, cannabinoids need to be solubilized for subsequent absorption in the gastro-intestinal tract With high first-pass metabolism, significant food effect and high potency, bioavailability…
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Many drug molecules that are currently in the market suffer from short half-life, poor absorption, low specificity, rapid degradation, and resistance development. The design and development of lipophilic prodrugs can provide numerous benefits to overcome these challenges. Fatty acids (FAs), which…
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The current study aimed to evaluate whether phosphatidylcholine-based formulations have suitable properties for liquid filling in hard capsules. Liquid or semisolid formulations were obtained with Miglyol 812 (medium chain triglycerides) or Softisan 378 (semisolid hard fat), respectively, in…
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The unique nanostructured matrix obtained by silica-lipid hybrids (SLHs) is well known to improve the dissolution, absorption, and bioavailability of poorly water-soluble drugs (PWSDs). The aim of this study was to investigate the impact of: (i) drug load: 3–22.7% w/w, (ii) lipid type: medium-chain…
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Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal…
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RECTAL DRUG DELIVERY Lipid excipients can be used to formulate suppositories, creams, ointments and foams. Suppocire® is a well-established brand of semisynthetic hard fat bases comprising fatty acid esters. Their physicochemical properties have been optimized to provide excellent drug delivery…
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Edible polymers refer to the polymeric materials which can be consumed by human beings, animals or microorganisms without any noxious effects towards health. They are categorized into polysaccharides, proteins and lipids, and have gained increasing application mainly in functional food industries…
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Liposomes, due to their mimetic cellular composition, are gaining great attention as release systems for lipophilic and hydrophilic molecules. However, liposomes can present a high tendency to degrade and aggregate into biological fluids and under storage conditions. To overcome these limitations,…
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Essential oils are volatile, complex products of plants as secondary metabolites and include terpenes and their oxygenated derivatives, such as alcohols, aldehydes, esters, ketones, phenols and oxides. In recent years, out of 3000 essential oils obtained from plant origin only 300 essential oils…
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