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Lipids
Implications of Solid Lipid Nanoparticles of Ganoderic Acid for the Treatment and Management of…
Purpose
The present work describes the systematic development of ganoderic acid (GA)–loaded solid lipid nanoparticles (SLNs) for the treatment of hepatocellular carcinoma (HCC).
Methods
A full factorial design was employed for optimization of the GA-loaded SLNs prepared by hot-homogenization…
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Self-Generating nano-emulsifying technology for alternatively-routed, bioavailability enhanced…
The self-generating nano-emulsifying drug delivery system (SNEDDS) is among the most effective approaches to enhance the oral bioavailability of a therapeutic agent, especially of a hydrophobic or poorly-water soluble drug. The methodology for SNEDDS preparation has been established on a number of…
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Nanostructured lipid carriers loaded with Halobetasol propionate for topical treatment of…
The aim of this research was the development and characterization of three gel dosage forms of Halobetasol propionate loaded lipid nanoparticles (HB-NLC) for the treatment of inflammatory skin diseases. A Pluronic gel (Pl-HB-NLC), a Carbopol gel (Cb-HB-NLC) and a Cremigel (Cg-HB-NLC), were…
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Enhanced Intestinal Absorption of Insulin by Capryol 90
Labrasol® is a self-emulsifying excipient that contains saturated polyglycolysed C6–C14 glycerides and this additive is known to improve the intestinal absorption of poorly absorbed drugs after oral administration. However, the effects of formulations similar to Labrasol® on the intestinal…
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Self-emulsifying drug delivery systems: About the fate of hydrophobic ion pairs on a phospholipid…
Purpose
To investigate the fate of hydrophobic ion pairs (HIPs) and self-emulsifying drug delivery systems (SEDDS) containing HIPs on a phospholipid bilayer.
Methods
HIPs of fluorescein (FL) were formed using the lipophilic cationic counter ion octadecylamine (OCT). HIPs were incorporated…
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Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: The effect of…
Silica-lipid hybrid (SLH) microparticles are a solidified lipid-based drug delivery system under investigation for their aptitude to enhance the oral bioavailability of poorly water-soluble drugs. The cholesterol-lowering agent, simvastatin (SIM), is poorly water-soluble and undergoes extensive…
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Characterization of lipid composition and diffusivity in OLA generated vesicles
Giant Unilamellar Vesicles (GUVs) are a versatile tool in many branches of science, including biophysics and synthetic biology. Octanol-Assisted Liposome Assembly (OLA), a recently developed microfluidic technique enables the production and testing of GUVs within a single device under highly…
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Nanoencapsulation approaches for oral delivery of vitamin A
Vitamin A is essential to human health. Encapsulation in lipid nanoparticles was used to overcome vitamin A poor water solubility in beverages. This work aimed to develop and characterize lipid nanoparticles, containing vitamin A, for food fortification, assuring its stability and oral…
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Current update on nanoplatforms as therapeutic and diagnostic tools: a review for the materials used…
In the last decade, the use of nanotheranostics as emerging diagnostic and therapeutic tools for various diseases, especially cancer, is held of great attention. Up to date, several approaches have been employed in order to develop smart nanotheranostics, which combine bioactive targeting on…
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Rifampin and Cis-2-Decenoic Acid Co-entrapment in Solid Lipid Nanoparticles as an Efficient…
Purpose
This study was performed to explore the physicochemical and anti-biofilm properties of rifampin (Rif) and cis-2-decenoic acid (C2DA) co-entrapped in solid lipid nanoparticles, Rif-C2DA-SLN, against staphylococcal biofilm.
Methods
The formulation was prepared by high-shear homogenization…
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