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Lipids
Influence of Oil Composition on the Transformation, Bioaccessibility, and Intestinal Absorption of…
The influences of liquid medium chain triglycerides (MCT) and solid glyceryl tristearate (GTS) contents in the lipid matrix of nanostructured lipid carriers (NLCs) on their delivering capacities for Cur were investigated herein by simulated gastrointestinal tract and Caco-2 monolayer models.
The…
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Design of ocular drug delivery platforms and in vitro – in vivo evaluation of riboflavin to…
Highlights
• Riboflavin salt showed higher nanoparticle drug loading than riboflavin base.
• Riboflavin salt leads to higher corneal drug transport than riboflavin base.
• Transcutol p (permeation enhancer) increased the effectiveness of riboflavin salt.
• Stearylamine (cationic…
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Drug Delivery Strategies for Poorly Water-Soluble Silymarin
Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable from milk thistle (Silybum marianum) seeds, is gaining an increasingly widespread clinical consensus as a natural remedy in the treatment of numerous chronic liver diseases such as cirrhosis and hepatocellular…
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Encapsulation of Ferulic Acid in Lipid Nanoparticles as Antioxidant for Skin: Mechanistic…
Ferulic acid, though used in formulations of skin-care and cosmetic products, suffers from the problems of poor stability and low aqueous solubility. Encapsulation into nanoparticle can be a viable route to overcome these inherent problems. In this proof-of-concept, we combine experimental studies…
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Formulation technologies and advances for oral delivery of novel nitroimidazoles and antimicrobial…
Antibiotic resistance has become a global crisis, driving the exploration for novel antibiotics and novel treatment approaches. Among these research efforts two classes of antibiotics, bicyclic nitroimidazoles and antimicrobial peptides, have recently shown promise as novel antimicrobial agents with…
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What’s new in the field of phospholipid vesicular nanocarriers for skin drug delivery
Over the last three decades, research in the field of phospholipid nanocarriers as tools to improve dermal and transdermal drug delivery has grown substantially. In particular, liposomes have been the target of studies aimed at reformulating vesicles with a greater ability to deliver drugs…
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Lipid Nanoarchitectonics for Natural Products Delivery in Cancer Therapy
Therapeutic applications of natural products have been noteworthy. A large sum of the population thrives on these products for countering multiple diseases and ailments. However, poor pharmacokinetic and pharmacodynamic profile of these molecules halted their progression as potential drug…
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In-Situ Forming Vesicles for the Improvement of the Bioavailability of Fexofenadine HCl
Drug absorption from the gastrointestinal tract (GIT) is one of the major problems affecting the bioavailability of orally absorbed drugs. This work aims to enhance Fexofenadine HCl oral bioavailability in vivo, the drug used for allergic rhinitis. In this study, novel spray-dried lactose-based…
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Nanoemulgel for Improved Topical Delivery of Retinyl Palmitate
Retinyl palmitate is a vitamin A ester belonging to the family of endogenous natural retinoid and used to treat various skin disorders like acne, skin aging, wrinkles, and dark spots, as well as to protect against psoriasis. Despite the known therapeutic benefits of retinyl palmitate, the…
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Nanostructured lipidic carriers for dual drug delivery in the management of psoriasis: Systematic…
In the present study, we selected two potential herbal drugs (Smilax china and Salix alba) and developed nano lipidic carriers (NLC) gel for safe and effective topical therapy against psoriasis. Optimization of formulation of NLCs was performed using Box-Behnken design by selecting three input…
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